Tag: molecule

Findings A UCLA research team has shown that using a truncated form of the CD4 molecule as part of a gene therapy to combat HIV yielded superior and longer-lasting results in mouse models than previous similar therapies using the CD4 molecule. This new approach to CAR T gene therapy — a type of immunotherapy that

A team of scientists from Brazil recently explored the abilities of the UK, South African, and Brazilian variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to evade host CD8+ T cell responses induced by natural infection or vaccination. The findings reveal reduced antigenic coverage for the P.2 Brazilian lineage, indicating its ability to evade

The University of Texas MD Anderson Cancer Center and Mirati Therapeutics, Inc. today announced a strategic research and development collaboration to expand the evaluation of Mirati's two investigational small molecules, potent and selective KRAS inhibitors – adagrasib (MRTX849), a G12C inhibitor in clinical development, and MRTX1133, a G12D inhibitor in preclinical development, as monotherapy and

For most proteins that have had their structure determined, this has been done using protein crystallography. When the macromolecular structure of a protein is determined in this way, it is firstly crystalized by supersaturation, which causes each protein molecule to stack with its neighbors in a repeating pattern. The sample then undergoes x-ray crystallography, which

The isolation of DNA was successfully carried out in 1869. However, its sequencing had to wait until the Human Genome Project was completed in 2003, more than a hundred years later. vitstudio | Shutterstock Modern genomics dates back to the 1970s, but its foundation was laid at least twenty years before this, with the creation

NRF2 is just one of thousands of critical proteins in the cell, but it is one that we now know a lot about. Once any molecule achieves a certain level of celebrity status, it tends to acquire a groupie following in the supplement market. Today, we have all manner of NRF enhancers, releasers, activators and

UT Southwestern researchers recently reported a basic science finding that might someday lead to better treatments for neurodegenerative diseases like a hereditary form of Lou Gehrig’s disease. In a study published in the journal Cell, Dr. Yuh Min Chook, Professor of Pharmacology and Biophysics, and Dr. Michael Rosen, Chair of Biophysics and an Investigator in

Dr. Robert Britton firmly believes every molecule is important. This chemist doesn’t want any molecule sitting unused on a laboratory shelf or in a fridge. “I want every molecule to have a purpose—that’s my ethos for our lab,” says Britton, a GlycoNet network investigator and professor at Simon Fraser University. With that spirit in mind,

A brain protein called tau is known to play a key role in the development of Alzheimer’s disease. Our brain cells have a “transport system” made of straight, parallel “roads,” along which food molecules, nutrients, and discarded parts of cells can travel. In a healthy brain, the protein tau helps these tracks to stay straight.