More people today are poised to explore space than ever before; those who do will experience the effects of microgravity on the human body. Recognizing the need for more data related to those effects, Medical University of South Carolina (MUSC) neuroradiologist Donna Roberts, M.D., and co-author Lonnie G. Petersen, M.D.,Ph.D., University of California San Diego,
Typically, damaged nerve fibres of the central nervous system (CNS) in the brain, the optic nerve and spinal cord don’t have the ability to regenerate. One of the pivotal reasons is that nerve fibres don’t produce any proteins that are necessary for their regeneration, or that they don’t produce enough of those proteins. The team
Researchers at Sahlgrenska Academy at the University of Gothenburg, Sweden, in collaboration with research groups in Finland, Canada, and Slovenia, have discovered a novel and unexpected function of nestin, the best known marker of neural stem cells. In the developing brain, the 3 main cell types, specifically neurons, astrocytes and oligodendrocytes, are generated from neural
Repetition is the best method for memorization, for neurons themselves. This is the principle behind what neurobiologists call sequence reactivations: during sleep, neurons in the hippocampus related to a task activate very quickly in turn in a precise order, which consolidates the memory of this task. Sequence reactivations are fundamental for long-term memorization and for
Virginia Tech Carilion Research Institute scientists have shown that mutations in specific genes that destroy motor neurons and thereby cause the devastating effects of amyotrophic lateral sclerosis — also known as ALS or Lou Gehrig’s disease — also attack sensory neurons. The discovery in today’s (Thursday, Nov. 8) Scientific Reports indicates that studying sensory neurons
Researchers from the Netherlands Institute for Neuroscience and Amsterdam UMC have disclosed the nature of how T cells protect the brain against harmful viruses. The results of the study, which are published in Nature Communications, are important for investigating the role of the immune system in numerous brain disorders. Immune system The immune system protects
An interdisciplinary and international research group led by Dr. Volker Busskamp from the Center for Regenerative Therapies Dresden at the TU Dresden (CRTD) has decoded the regulatory impact on neuronal survival of a small non-coding RNA molecule, so-called miRNA, at the highest resolution to date. This deciphering of gene regulation primes applications for strengthening neurons
Simulations with animal models meant to mirror galactic cosmic radiation exposure to astronauts are raising red flags for investigators at Georgetown University Medical Center (GUMC) about the health of astronauts during long voyages, such as to Mars. Their most recent study, published in the Proceedings of the National Academy of Sciences (PNAS), suggests that deep
About every five seconds or so we close our eyes and blink to moisten them. During this brief moment no light falls on our retina yet it is not constantly dark and we continue to observe a stable picture of our environment. The brain seems to remember the percepts that have just happened. Caspar Schwiedrzik
Spinal cord stimulation and physical therapy have helped a man paralyzed since 2013 regain his ability to stand and walk with assistance. The results, achieved in a research collaboration between Mayo Clinic and UCLA, are reported in Nature Medicine. With an implanted stimulator turned on, the man was able to step with a front-wheeled walker
Zombie cells are the ones that can’t die but are equally unable to perform the functions of a normal cell. These zombie, or senescent, cells are implicated in a number of age-related diseases. And with a new letter in Nature, Mayo Clinic researchers have expanded that list. In a mouse model of brain disease, scientists
Ever wonder why some people seem to feel less pain than others? A study conducted at Wake Forest School of Medicine may have found one of the answers — mindfulness. “Mindfulness is related to being aware of the present moment without too much emotional reaction or judgment,” said the study’s lead author, Fadel Zeidan, Ph.D.,
UCLA bioengineers have demonstrated that a gel-like material containing tiny magnetic particles could be used to manage chronic pain from disease or injury. Broadly, the study demonstrates the promising use of biomechanical forces that push and pull on cells to treat disease. “Much of mainstream modern medicine centers on using pharmaceuticals to make chemical or
Studying transthyretin amyloidoses-a group of progressive nerve and cardiac degenerative diseases caused by the buildup of misfolded transthyretin (TTR) proteins in the body-has long been hampered by the lack of animal models of the disease. Mice, for instance, don’t show the same symptoms as humans, even when misfolded TTR accumulates in their organs. Now, scientists
Researchers have found that women who play soccer may be more at risk than their male counterparts. According to a new study published in the journal Radiology, female soccer players exhibit more extensive changes to brain tissue after repetitive ‘heading’ of the soccer ball. Soccer is the most popular competitive sport in the world, and
When a muscle is acutely injured — whether through accidental strain or intentional weight lifting — special repair cells called fibro-adipogenic progenitors (FAPs) rush to the rescue. These cells coordinate the activity of the immune system and muscle stem cells to replace and repair the torn tissue. Now, scientists at Sanford Burnham Prebys Medical Discovery
The cerebral cortex is a highly developed brain region, which allows intellectual functions such as conscious perception, anticipation of events and language. These functions are mediated by specific sets of neuronal circuits. To understand how these circuits emerge during development, researchers from the University of Geneva (UNIGE), Switzerland, in collaboration with an American team, investigated
A deadly feature of acute lymphoblastic leukemia (ALL) is its invasion of the central nervous system. ALL in the central nervous system is very difficult to treat, because most drugs are blocked from the organ system due to a “blood-brain barrier” designed to protect the brain. How cancer cells enter the central nervous system has
Stressful situations affect the brain and body differently in people with schizophrenia compared to people without the mental illness or individuals at high risk for developing psychosis, a new CAMH study shows. The relationship between two chemicals released when people experienced stress — one released in the brain and the other in saliva — differs
A study of rat brain slices published in JNeurosci demonstrates how nicotine interacts with cells that regulate the output of a brain region involved in habit formation. The research could inform efforts to help people quit smoking and avoid relapse. The addictive qualities of nicotine have been attributed to the brain’s reward system. However, recent
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