Tag: Neuropathy

An international team of BHF-funded researchers may have discovered why some people experience muscle pain after taking statins. The research, published in JACC: Basic to Translational Science, could help doctors prevent a known side effect of statins and ensure people are able to reap the benefits of the life-saving drugs. According to the research, statins

Sortilin, which is a protein expressed on the surface of nerve cells, plays a crucial role in pain development in laboratory mice — and in all likelihood in humans as well. This is the main conclusion of the study ‘Sortilin gates neurotensin and BDNF signalling to control peripheral neuropathic pain’, which has just been published

Typically, damaged nerve fibres of the central nervous system (CNS) in the brain, the optic nerve and spinal cord don’t have the ability to regenerate. One of the pivotal reasons is that nerve fibres don’t produce any proteins that are necessary for their regeneration, or that they don’t produce enough of those proteins. The team

Healthy muscle cells rely on the protein dysferlin to properly repair the sarcolemmal membrane, a thin specialized membrane that serves a vital role in ensuring that muscle fibers are strong enough and have the necessary resources to contract. Mutations in the DYSF gene that produces this essential protein causes limb girdle muscular dystrophy type 2B

Studying transthyretin amyloidoses-a group of progressive nerve and cardiac degenerative diseases caused by the buildup of misfolded transthyretin (TTR) proteins in the body-has long been hampered by the lack of animal models of the disease. Mice, for instance, don’t show the same symptoms as humans, even when misfolded TTR accumulates in their organs. Now, scientists

A team of researchers at Johns Hopkins have found that activating nerve cell receptors along two chemical pathways — one that has previously been linked to how the brain senses “itch” — may improve pain relief when combined with conventional ways to blunt pain using opioid drugs, such as morphine. The study results, published in

Most of the roughly 15.5 million cancer survivors in the U.S. receive chemotherapy, and roughly 65 percent develop some degree of the chemotherapy-induced nerve damage known as peripheral neuropathy. Peripheral neuropathy simply means nerves outside of the brain and spinal cord are affected, and symptoms include numbness and tingling in extremities, and in about 30

Giving opioids to animals to quell pain after surgery prolongs pain for more than three weeks and primes specialized immune cells in the spinal cord to be more reactive to pain, according to a new study by the University of Colorado Boulder. The authors say the paradoxical findings, if replicated in humans, could have far-reaching