A potential new target for treatment has been identified in an aggressive form of bladder cancer, Mount Sinai researchers report in a recent study. Bladder cancers are categorized into subtypes based on molecular features. These subtypes are associated with different prognoses and responses to conventional treatments such as chemotherapy. A type of bladder cancer called
The complexity of the human brain presents scientists with immense challenges as they try to find new treatments for a host of diseases and conditions. But the advent of a new technology known as single-cell RNA sequencing is opening a window into how the brain works. Researchers at the Translational Genomics Research Institute (TGen), an
There’s no doubt that new mums have a lot on (and in) their hands: a new role, a new baby, and a new lifestyle. So much new-ness can certainly be overwhelming, but thankfully, there are guidebooks, articles, paediatricians—and occasionally unsolicited advice, too—to help answer the most obvious and obscure questions. But if issues arise, when should
A study led by Luísa Lopes, Group Leader at Instituto de Medicina Molecular João Lobo Antunes (iMM; Portugal) and published today in the prestigious journal Molecular Psychiatry, describes a new mechanism involved in memory loss associated with aging. The work developed over three years by a team of Portuguese, French and German scientists now shows
Oral squamous cell carcinomas (OSCCs) are the most common head and neck cancers, but are often diagnosed late. Now, researchers in Germany have developed a new cell-based test that could help provide earlier and more reliable diagnosis of OSCCs. Writing in Science Physical Oncology, the researchers explain how they tested the mechanical properties of OSCC
Severe gaps in staffing and outdated coverage benchmarks point to the critical need for evaluating and updating standards for infection preventionist (IP) staffing levels, according to two new studies that explored infection prevention and control resourcing across a variety of healthcare settings. The studies were published in the American Journal of Infection Control (AJIC), the
Northwestern Medicine scientists have discovered that some neurons affected by amyotrophic lateral sclerosis (ALS) display hypo-excitability, using a new method to measure electrical activity in cells, according to a study published in Stem Cell Reports. “The excitability changes observed in these patient neurons most likely represent the early steps in the disease process,” said Evangelos
Dairy will always have a place in our world, but many of us are looking for more plant-based options wherever possible, and dairy-free and vegan spins on our favorite foods, from whipped cream to ice cream, are everywhere this season. In fact, the demand for plant-based products grew over 8 percent last year according to
Of the major illnesses facing humanity, Alzheimer’s disease (AD) remains among the most pitiless and confounding. Over a century after its discovery, no effective prevention or treatment exists for this progressive deterioration of brain tissue, memory and identity. With more people living to older ages, there is a growing need to clarify Alzheimer’s disease risk
Starbucks’ motto for the summer must be "can’t stop, won’t stop" because the powerhouse coffee chain continues to add delicious new drinks to its menu. Just a couple of weeks ago, it added three new items to its permanent menu, one of them being the Serious Strawberry Frappuccino. And now? We have a new refresher
Giving the drug sodium thiosulphate after chemotherapy reduces hearing loss in children treated for liver cancer, according to findings published in the New England Journal of Medicine today. Results from the Cancer Research UK funded SIOPEL-6 clinical trial show that giving sodium thiosulphate (STS), after a type of chemotherapy called cisplatin, reduces hearing loss by
Nurse practitioners (NPs) are providing an increasing proportion of primary care, which is in short supply in many areas of the country. NPs deliver quality care in retail clinics, community health centers, rural clinics, and in primary care and specialty medical practices. In an article published today in the New England Journal of Medicine, University
New genetic testing has been developed at the University of Oxford to detect early signs of a potentially fatal condition that can also develop into full blown leukaemia in children with Down’s syndrome. Despite children with Down’s syndrome having around a one in 50 chance of developing acute myeloid leukaemia (AML), compared to a one
An international team of scientists have developed a new way to screen for age-related cognitive decline at home using a test which asks people to detect sounds and flashes on their laptop or phone. Developed by researchers from Switzerland and the UK, the study shows that the simple, cost-effective test may be used to help
As far as yogurt consumers go, I’m a big one. Early-onset osteoporosis runs in my family, but since I don’t eat a lot of cheese or milk, I make a point to have at least one serving of yogurt every day, if not two, to make sure I’m getting plenty of calcium. But recently, I
RNA-Seq is a new next-generation assay that can detect gene fusions in solid tumor cells with high accuracy and excellent reproducibility. According to a new report in The Journal of Molecular Diagnostics, the assay detected 93 percent of gene fusions identified by currently available methods with no false positives. Importantly, gene fusions missed by other
Purdue University researchers have identified a new compound that in preliminary testing has shown itself to be as effective as antibiotics approved by the Food and Drug Administration to treat life-threatening infections while also appearing to be less susceptible to bacterial resistance. The compound, called F6, has been potent against antibiotic-resistant pathogens such as methicillin-resistant
Treatment changes including the advent of targeted and immune therapies have dramatically improved survival for blood cancers, but new report calls for improved evaluation of poorly understood side effects that may develop over time.—- Survival rates for blood cancers—including lymphoma, myeloma and some types of leukaemia—have dramatically increased over the past decade, due in great
Researchers at Baylor College of Medicine and Texas Children’s Hospital have identified unexpected new key players in the development of an early onset form of Parkinson’s disease called Parkinsonism. These key players are ceramides, a family of lipid molecules that are found within cell membranes. The researchers propose that ceramides are the linchpin that connects
Genetically engineered bacteria are showing promise as a new treatment for constipation, researchers at the Mayo Clinic Center for Individualized Medicine have discovered in a mouse study. The finding is significant in part because there are few approved constipation remedies on the market. The research is published in Cell Host & Microbe. Because the community
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