Tag: Novel

New research from Cleveland State University could lead to improved antiviral treatments and vaccines for COVID-19 and similar viruses. An article published this week in the American Society of Microbiology’s Journal of Virology provides significant insights into the host-virus relationship of SARS-CoV-2, the virus that causes COVID-19. The research team, led by Barsanjit Mazumder, Ph.D.,

Chronic back pain is the leading cause of disability worldwide. In the United States, patients spend up to $300 billion each year to treat the condition, according to a 2012 study published in the Journal of Pain. However, common therapies such as surgery and steroid injections intended to address physical origins of back pain have

Science is examining the brain’s neural activity for applications ranging from innovative therapies for brain-related injuries and disease to computational learning architectures for artificial intelligence and deep neural networks. A research team has developed a tool that lets researchers see more of a live mouse’s brain, to make discoveries that can advance research into the

A novel therapy engineered by Northwestern Medicine investigators improved progression-free and overall survival for patients with newly diagnosed malignant gliomas, according to results from a recent phase I clinical trial published in The Lancet Oncology. In the study, investigators evaluated the safety of a novel therapy called NSC-CRAd-S-pk7 in patients newly diagnosed with malignant gliomas.

A new positron emission tomography (PET) radiotracer can detect abdominal aortic aneurysms (AAAs) and potentially predict when they will rupture, according to research presented at the Society of Nuclear Medicine and Molecular Imaging 2021 Annual Meeting. Targeting a novel biomarker associated with AAA, the radiotracer is effective both in diagnosis and in providing information to

In a recent discovery by University of Minnesota Medical School, researchers uncovered a new way to potentially target and treat late-stage colorectal cancer—a disease that kills more than 50,000 people each year in the United States. The team identified a novel mechanism by which colorectal cancer cells evade an anti-tumor immune response, which helped them

A team of scientists, led by researchers at Northwestern University, Shirley Ryan AbilityLab and the University of Illinois at Chicago (UIC), has developed novel technology promising to increase understanding of how brains develop, and offer answers on repairing brains in the wake of neurotrauma and neurodegenerative diseases. Their research is the first to combine the

A deadly novel coronavirus outbreak, which has infected more than 4,500 people and spread to 15 countries since emerging in China, has also spawned many false claims on social media. Here’s a selection of misinformation debunked by AFP’s Fact Check service. Sydney food not contaminated In Australia, multiple Facebook posts shared hundreds of times claimed

A collaboration led by scientists at Tokyo University of Agriculture and Technology (TUAT), Japan, has discovered a novel amyloid protein that induces amyloidosis in rats. This new amyloid protein is known to be the lipopolysaccharide binding protein (LBP) and accumulated very frequently in the mammary gland of aged rats. Although LBP was identified as an

A clinical trial testing the toxicity of a KRAS inhibitor demonstrated early promising antitumor activity and few adverse side effects in patients with advanced non-small cell lung cancer harboring KRAS G12C mutation, according to research presented today at the IASLC 2019 World Conference on Lung Cancer, hosted by the International Association for the Study of

In a landmark study, scientists at Houston Methodist Research Institute discovered what makes white blood cell counts spike in individuals who have high cholesterol, possibly leading to new therapies for heart disease. Led by Longhou Fang, Ph.D., an associate professor in the Center for Cardiovascular Regeneration, and his postdoctoral fellow Qilin Gu, Ph.D., the team

Autoimmune diseases, including type 1 diabetes and multiple sclerosis, arise when the body’s immune cells attack itself. Current treatments eliminate these misfunctioning immune cells, but also destroy normal, protective immune cells, leaving patients susceptible to immune deficiency and opportunistic infections. Researchers at University of Utah Health have developed a new approach that targets the misfunctioning

Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous, cancerous and metastatic PDAC cell lines. GZ17-6.02 affects acetylation of the genes, reduces transcription of major transcription factors, sonic hedgehog pathway proteins, and stem cell markers. Dr.

The journey of muscle rehabilitation can be long and arduous, and requires strong perseverance from the patient. Now, researchers from the National University of Singapore (NUS) are making the recovery process much easier for patients with an ingenious medical device capable of regenerating muscles in a non-invasive and painless manner. The device, named MRegen, makes

Researchers have developed a new nuclear medicine tracer that could improve diagnosis and treatment of non-small cell lung cancer. Research published in the November issue of The Journal of Nuclear Medicine found that the new tracer, 99mTc-HYNIC-cMBP, produced clearer images in less time than currently used tracers and was more rapidly eliminated from the body,

More than two-thirds of women with ovarian cancer have high-grade serous carcinoma (HGSC). Up to 90 percent of HGSCs are not detected until they are beyond the ovaries or fallopian tubes, at which point it may not be possible to fully remove the tumor. Many of these cancers are now known to originate in the

Scientists in Dresden, Germany, have been successful in mimicking mechanisms of Alzheimer’s disease in a novel, stem cell-based model system that reproduces features of human brain tissue. This experimental tool can be used to study mechanisms of pathology and help to find new therapeutic approaches, the researchers say. Their results, published in the journal Developmental

Research spearhead by first author Isabel Puig, Post-Doctoral Fellow of the Vall d´Hebron Institute of Oncology’s (VHIO) Stem Cells & Cancer Group, directed by Principal Investigator Héctor G. Palmer, has culminated in the discovery of a biomarker to identify dormant tumor cells (DTC), also known as slow-cycling cancer cells (SCCC), that, in their dormant state,

Hospital-acquired infections are a serious threat to patient lives, especially with the rise of antibiotic-resistant bacteria. One drug that may prove helpful in the fight against these infections is monophosphoryl Lipid A (MPLA). MPLA stimulates the immune system to help fight off invaders like bacteria or fungi. It is already used clinically to help make

Researchers at the University of California, Irvine School of Medicine have discovered the first example of a novel mode of neurotransmitter-based communication. The discovery, published in Nature Communications, challenges current dogma about mechanisms of signaling in the brain, and uncovers new pathways for developing therapies for disorders like epilepsy, anxiety and chronic pain. Voltage-gated potassium