Tag: nuclear

A nuclear gatekeeper that regulates bone formation

Important insights into the cellular processes underlying healthy bone formation and development have been gleaned by a RIKEN-led study into a previously unknown bone disorder1. Many bone disorders have genetic origins. Advances in genetics are helping scientists track down the mutations responsible for them. Shiro Ikegawa of the RIKEN Center for Integrative Medical Sciences has

Nuclear magnetic resonance insights set stage for next-gen targeted cancer therapies for adults and children

Scientists at St. Jude Children’s Research Hospital have visualized previously unknown structures of the ABL kinase, offering insight for designing the next generation of targeted therapies for adult and childhood cancers. The work will advance understanding of treatment resistance to targeted cancer therapies. The findings appear as an advance online publication today in Science. Central