Studies have demonstrated a connection between obesity and a person’s risk of developing colon and other gastrointestinal cancers. Now, scientists are investigating approaches that can break this relationship. In an article in the journal Nature Reviews Gastroenterology & Hepatology, UNC Lineberger’s Stephen Hursting, Ph.D., MPH, along with Cornelia Ulrich, Ph.D., MS, the director of the
Obese mothers who lose weight through bariatric surgery can have safer deliveries. The positive effects are many, including fewer caesarean sections, infections, tears and haemorrhages, and fewer cases of post-term delivery or uterine inertia. This according to an observational study by researchers at Karolinska Institutet in Sweden published in PLOS Medicine. Today, more than one
Researchers at University of California San Diego School of Medicine have discovered using mice and human clinical specimens, that caspase-2, a protein-cleaving enzyme, is a critical driver of non-alcoholic steatohepatitis (NASH), a chronic and aggressive liver condition. By identifying caspase-2’s critical role, they believe an inhibitor of this enzyme could provide an effective way to
An international research team led by the University of California, Irvine has identified a system of communication networks that exists among organs and tissues that regulate metabolism. Findings from their study provide, for the first time, a detailed “atlas” illustrating how the body creates and uses energy, and how imbalances in the networks may impact
A sedentary lifestyle combined with a diet dominated by processed foods has widely resulted in a range of conditions including diabetes, obesity, and high blood pressure, which are known collectively as metabolic syndrome. Although many insights into the causes of metabolic syndrome have been made, much remains to be understood about the complex interplay among
There are diseases or problems we tend to associate with older people but unfortunately, they can happen at any time. Here’s what to be aware of… Arthritis It’s a common misconception that arthritis is an old person’s disease. While osteoarthritis is caused by wear and tear, and therefore most common among those over 65, rheumatoid
An international team of researchers has uncovered a destructive mechanism at the molecular level that causes a well-known phenomenon associated with obesity, called leptin resistance. They found that mice fed a high-fat diet produce an enzyme named MMP-2 that clips receptors for the hormone leptin from the surface of neuronal cells in the hypothalamus. This
Lipid droplets: they were long thought of merely as the formless blobs of fat out of which spare tires and muffin tops were made. But these days, they’re “a really hot area of research,” says Michael Welte, professor and chair of biology at the University of Rochester. That’s in part because lipid droplets have been
Excessive body fat is associated with negative effects on female fertility and pregnancy. In mice, maternal obesity impairs proper development of egg precursor cells called oocytes. In a recent paper published in Molecular & Cellular Proteomics, Qiang Wang and colleagues at the State Key Laboratory of Reproductive Medicine in China describe the link between poor
Today, nearly 40 percent of U.S. adults and 21 percent of youth are obese. This trend is on the upswing and the worldwide population is becoming more obese – which is increasing the risk of other conditions like Type 2 diabetes and cardiovascular disease whose prevalence has doubled globally in the last 30 years. But
A newly published study by researchers from the University of Colorado School of Medicine has identified a potential therapeutic target for treating obesity and diabetes. The scientists studied the biological function of an epigenetic modifier known as histone deacetylase 11 (HDAC11), and determined that deleting it in mice stimulates the formation of brown adipose tissue.
Mothers lead the way for their children. And new research finds that the paths that moms walk (or the couches they sit and smoke on) make a powerful difference in their children’s propensity to become obese. A study that tracked close to 17,000 female nurses and their 24,289 kids has found that women who practiced
Scientists have found that it is the structure of collagen, rather than the amount, that leads to the devastating condition of lung fibrosis, according to a report in the journal eLife. The study provides the first evidence in humans that altered collagen structure affects tissue stiffness during progression of lung fibrosis and identifies a potential
WEDNESDAY, July 4, 2018 — Moms can play a big role in combating America’s childhood obesity epidemic, researchers contend. The key: kids are less likely to be obese if their mothers follow five healthy habits, according to the report from Harvard. The five habits are: eating a healthy diet; exercising regularly; maintaining a healthy body
The results showed that ageing, combined with a high fat and high sugar diet, results in increased inflammation and stress in the hippocampus — responsible for long-term memory While ageing has been long identified as a significant risk factor for Alzheimer’s disease, a new study shows that obesity during middle age may contribute to the
Gestational diabetes is a common problem faced by many women during pregnancy, where they develop a resistance to insulin and have high blood sugar during pregnancy. It tends to occur around the 24th week of pregnancy, and becomes normal after the pregnancy is over. Why it happens “The condition arises because the action of insulin
It may seem like a contradiction, but more adults in the U.S. say they are exercising at the same time more of them are becoming obese. About 24 percent of adults last year said they exercise enough each week to meet government recommendations for both muscle strengthening and aerobic exercise, according to a large annual
Baby food in the firing line over obesity: Officials will examine if infant purees are too sugary, report reveals To tackle childhood obesity, Government will review products aimed at infants Similar report released in 2016 led to the sugary drinks tax in April this year The UK Government aims to halve children obesity rates by
New research warns that the normalisation of ‘plus-size’ body shapes may be leading to an increasing number of people underestimating their weight—undermining efforts to tackle England’s ever-growing obesity problem. While attempts to reduce stigmatisation of larger body sizes—for example with the launch of plus-size clothing ranges—help promote body positivity, the study highlights an unintentional negative
The importance of the human brown adipose tissue (BAT) has become clearer during the past ten years. Using positron emission tomography, PET, it was shown that adult humans have functional BAT. Coldness is an effective activator of the BAT metabolic function but, in rodents, eating has the same effect. Now, the researchers at Turku PET
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