Tag: pathway

Bipolar disorder affects millions of Americans, causing dramatic swings in mood and, in some people, additional effects such as memory problems. While bipolar disorder is linked to many genes, each one making small contributions to the disease, scientists don’t know just how those genes ultimately give rise to the disorder’s effects. However, in new research,

Bipolar disorder affects millions of Americans, causing dramatic swings in mood and, in some people, additional effects such as memory problems. While bipolar disorder is linked to many genes, each one making small contributions to the disease, scientists don’t know just how those genes ultimately give rise to the disorder’s effects. However, in new research,

In breakthrough colon cancer research, scientists at ChristianaCare’s Helen F. Graham Cancer Center & Research Institute have discovered a link between two key signaling pathways crucial to the development and growth of colon cancer. The study is published today in the journal PLOS ONE. The scientists identified the link between the retinoic acid or RA

Reversing runaway inflammation in the bone marrow could lead to major breakthroughs in treatments for some blood cancers, according to a new publication by scientists at Hackensack Meridian Health’s Center for Discovery and Innovation. The CDI team’s findings could ultimately improve cancer treatments for people of advanced age, like that of adult acute myeloid leukemia

A team of researchers affiliated with several institutions in the U.S. and one in the U.K. has found that blocking a certain inflammatory pathway in mice protects tendons from injury. In their paper published in the journal Science Translational Medicine, the group describes their study of tendinopathies and possible ways to prevent them. Most people

During an ischemic attack, the heart is temporarily robbed of its blood supply. The aftermath is devastating: reduced heart contractility, heart cell death, and heart failure. Contributing to these detrimental changes is a signaling molecule, G protein-coupled receptor kinase 2 (GRK2), which following ischemia accumulates in mitochondria, the energy-producing powerhouses of cells. Now, a Temple-led

FRIDAY, Aug. 3, 2018 — Dermal absorption is a more important pathway than inhalation for the intake of low-molecular-weight polycyclic aromatic hydrocarbons (PAHs) during barbecuing, according to a study published recently in Environmental Science & Technology. Jia-Yong Lao, from Jinan University in Guangzhou, China, and colleagues collected and analyzed urine samples for nine hydroxyl (OH)-PAHs

Innate fear is an essential emotion for animals to avoid danger in a severe natural environment. Rodents kept in a laboratory also show instinctive fear behavior against the smell of predators such as foxes, cats or snakes despite having never seen them. This innate fear represents an evolutionarily conserved and genetically encoded survival mechanism. However,