An oxysterol that accumulates in the eye with age can transform choroidal endothelial cells; interfering with the process might help patients with treatment-resistant age-related macular degeneration. The latest research from the laboratory of John A. Moran Eye Center physician-scientist Mary Elizabeth Hartnett, MD, reveals how an oxidized form of cholesterol can change choroidal endothelial cells
Researchers at the University of Toronto have discovered how a brief disruption to a molecular pathway in the guts of mice before they are born can compromise adult immunity to a common and often deadly intestinal virus. The researchers found that in utero inhibition of molecular signalling in the ‘lymphotoxin pathway,’ long known as important
Using functional magnetic resonance imaging (fMRI) to monitor subjects’ brain activity as they were shown images of art, architecture or natural landscapes, the team found that in the visual parts of the brain, these different types of images led to very different patterns of activity, even across images all judged by subjects to be aesthetically
Fingers crossed! Chris Pratt is hoping to gain his 6-year-old son Jack’s approval by taking him on a wild ride. “He’s really excited,” the actor, 40, told Us Weekly exclusively at the Jurassic World — The Ride grand opening on Monday, July 22. “I think we’re going to try to do it this week. …
Cannabis resin and herbal cannabis have significantly increased in potency and in price, according to the first study to investigate changes in cannabis across Europe. The study, published today in the journal Addiction by researchers from the University of Bath and King’s College London, draws on data collected from across 28 EU Member states, as
Recent advances in scientific understanding of how posttraumatic stress disorder (PTSD) develops and persists may lead to more effective treatment and even prevention of this debilitating disorder, according to the May/June special issue of Harvard Review of Psychiatry. A growing body of evidence helps psychiatrists to understand the aspects of brain structure and function involved
Melanoma, a relatively rare but deadly skin cancer, has been shown to switch differentiation states—that is, to regress to an earlier stage of development—which can lead it to become resistant to treatment. Now, UCLA researchers have found that melanomas can be divided into four distinct subtypes according to their stages of differentiation. Cell subtypes that
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