Tag: Prostate Cancer

Men with inflammatory bowel disease have four to five times higher risk of being diagnosed with prostate cancer, reports a 20-year study from Northwestern Medicine. This is the first report to show men with inflammatory bowel disease have higher than average PSA (prostate-specific antigen) values, and this group also has a significantly higher risk of

Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now found a cause for the frequent catastrophic events in the genetic material of cancer cells that have only been known for a few years: If an important DNA repair system of the cells has failed, this promotes fragmentation and defective assembly of the

There are more than 200 bones in the human body. Bone is formed during embryonic and postnatal skeletogenesis by two distinct, well-organized processes, intramembranous and endochondral ossification. Mesenchymal stem cells differentiate into chondrocytes to form a cartilaginous template, which, for long bones, induces bone formation through endochondral ossification. Extracellular signal-regulated kinase 5 (Erk5), which is

Routine testing for prostate cancer is not recommended for most men because the benefit is small and uncertain and there are clear harms, say a panel of international experts in The BMJ today. But they acknowledge that some men, such as those with a family history of prostate cancer, may be more likely to consider

“Lego block” artificial cells that can kill bacteria have been created by researchers at the University of California, Davis Department of Biomedical Engineering. The work is reported Aug. 29 in the journal ACS Applied Materials and Interfaces. “We engineered artificial cells from the bottom-up — like Lego blocks — to destroy bacteria,” said Assistant Professor

Patients with muscle-invasive bladder cancer have been shown to benefit from chemotherapy prior to surgical removal of the bladder. But which type of chemotherapy leads to the best outcomes in terms of complete response rates or cancer control? Moffitt Cancer Center researchers examined data from more than 800 surgical patients with advanced bladder cancer. The

A UCLA-led study has found that a treatment that uses a bacteria-like agent in combination with an immunotherapy drug could help some people with advanced melanoma, an aggressive form of skin cancer, live longer. The research showed that using the immunotherapy drug pembrolizumab and the experimental agent SD-101, a sequence of nucleic acids that mimics

Certain molecular drivers of cancer growth are “undruggable” — it’s been nearly impossible to develop chemicals that would block their action and prevent cancer growth. Many of these molecules function by passing cancer-promoting information through a gate in the nucleus, where the instructions are carried out. Researchers at the Sidney Kimmel Cancer Center — Jefferson

The fight against cystic fibrosis (CF) has taken a major step forward, with pioneering research by University of Adelaide scientists showing that cells causing the debilitating genetic disorder could be successfully replaced with healthy ones. The research published in the journal Stem Cell Research and Therapy applies cell transplantation therapy, normally used in bone marrow

A new study of prostate cancer in 202 men, whose cancers had spread and were resistant to standard treatment, found that a surprisingly large number of these cancers — about 17 percent — belong to a deadlier subtype of metastatic prostate cancer. Previously, it was thought that these cancers constituted less than 1 percent of

It is currently recommended in Europe that screening for hepatitis C virus (HCV) should target people at high risk of infection. In France, public health data suggest that in 2014 approximately 75,000 people aged 18 to 80 were infected by HCV, but were unaware of their status. In at least one in ten cases, these

A research team found a novel function of fibroblast growth factor 2 (FGF2), a self-renewal factor for spermatogonial stem cell (SSC) which is the origin of the sperm production. Although it has demonstrated that both FGF2 and glial cell line-derived neurotrophic factor (GDNF) is indispensable for SSC self-renewal and survival in vitro, the present study

Researchers using automated breast density measurements have found that women with mammographically dense breast tissue have higher recall and biopsy rates and increased odds of screen-detected and interval breast cancer, according to a large new study from Norway published online in the journal Radiology. The study supports automated measurements as a future standard to ensure

A new microscope system can image living tissue in real time and in molecular detail, without any chemicals or dyes, report researchers at the University of Illinois. The system uses precisely tailored pulses of light to simultaneously image with multiple wavelengths. This enables the researchers to study concurrent processes within cells and tissue, and could

Using a targeted therapy to block a protein that suppresses T cell activity could improve cancer treatment with immune checkpoint inhibitors, researchers at The University of Texas MD Anderson Cancer Center report today in the Journal of Clinical Investigation. The team showed that EZH2 is elevated in immune T cells in patients after treatment with

An international team of researchers including USC scientists has found scores of new genetic markers in DNA code that increase prostate cancer risk — powerful knowledge likely to prove useful to detect and prevent the disease. Focusing on DNA of more than 140,000 men worldwide, researchers were able to identify 63 new genetic markers associated

Researchers have developed a new type of sensor that acts like Velcro® for prostate cancer cells, sticking them to a modified frosted glass slide, like those used in science classes, so that they can be identified from blood samples. The low-cost method, reported in ACS Applied Materials & Interfaces, could help doctors better diagnose and

Anyone who’s taken a bite of a sandwich with too much spicy mustard or a piece of sushi with too much wasabi can attest to the tear-inducing sensation these condiments can cause. These loud warnings to the nervous system of exposure to potentially harmful chemicals are triggered by TRPA1, a calcium channel protein sometimes referred

Publication in Nature Cell Biology: researchers at the Université libre de Bruxelles, ULB define for the first time the mechanisms responsible for the mammary gland development. The mammary gland is the tissue that produces the milk during lactation, allowing the survival of young mammalian offspring. The mammary gland is composed of two main lineages: the

A new study finds that one of the toughest characters in the immune system, the macrophage, has a nurturing side, at least when it comes to guarding the developing breast. The study published online this week in the journal Science found that macrophages play an important role in maintaining the mammary gland’s stem cell niche,