A decade-long study has identified the factor produced by a common species of skin bacteria that triggers eczema, in a breakthrough of our understanding of the condition. The discovery of a missing link by an international team led by University of Manchester scientists could lead to new treatments for the sometimes debilitating skin condition which
Researchers at the Netherlands Cancer Institute have discovered salivary glands in a previously unknown location. This is potentially great news for patients with head and neck tumors: Radiation oncologists will now be able to circumvent this area to avoid potential complications. The research is forthcoming in Radiotherapy & Oncology. Advanced technology allows scientists to visualize
Researchers with the U.S. Army Futures Command are part of a team that tested alternative ways to measure COVID-19 antibody levels, resulting in a process that is faster, easier and less expensive to use on a large scale. Their method holds promise for accurately identifying potential donors who have the best chance of helping infected
Contact-tracing and exposure-notification apps are a new technology rapidly developed and launched to respond to the COVID-19 global health crisis. The development of such applications is placing governments, corporations, and citizens around the world into an ongoing ethical design experiment resulting in potentially life-saving outcomes but also potential risks. During the summer of 2020, design
New research has uncovered the previously unknown presence of CD19—a B cell molecule targeted by chimeric antigen receptor (CAR) T cell immunotherapy to treat leukemia, lymphoma, and multiple myeloma—in brain cells that protect the blood brain barrier (BBB). This discovery may potentially be the cause for neurotoxicity in patients undergoing CD19 directed CAR T cell
Capecitabine is a chemotherapy drug used for breast and colorectal cancer. It can extend survival rate by nearly 10%. However, recent studies revealed that almost 50% of patients develop palmar-plantar erythrodysesthesia, a skin reaction also called hand-foot syndrome with mild to serious symptoms. Up to 17% of these patients can have a burning pain in
Even as the first wave of the pandemic still roils, fears are rising of a second crush of COVID-19 infections. But because the novel coronavirus is, well, novel, no one can yet say if that will happen. One thing is certain, though, another viral wave is coming: flu season. Influenza season occurs during the cold
Various diseases of the digestive tract, for example severe intestinal inflammation in humans, are closely linked to disturbances in the natural mobility of the intestine. What role the microbiome—i.e. the natural microbial community colonizing the digestive tract—plays in these rhythmic contractions of the intestine, also known as peristalsis, is currently the subject of intensive research.
Otago researchers studying the COVID-19 virus (SARS-2) have discovered potential target points on its genome, which may contribute to future treatments for the virus. While their laboratory was locked down during the Level 4 period, Ph.D. student Ali Hosseini and Professor Alex McLellan from the Department of Microbiology and Immunology worked from their homes to
A small team of researchers from the University of Chicago, Pennsylvania State University, and Aarhus University has found that people who are exposed to end-of-the-world movies may be more resilient when dealing with the real-life ongoing pandemic. They have written a paper describing questioning volunteers about movies they had seen and their real pandemic experiences.
When an embryo develops, a wide variety of proteins and enzymes trigger a series of biochemical reactions. The development of the lymphatic vasculature is crucially dependent on one specific protein—the growth factor VEGF-C. In order to become biologically active and to initiate downstream signaling events, the protein must first undergo processing steps. Thus far it
Positron emission tomography (PET), an advanced medical imaging technique, has been widely used in various clinical applications, including tumor detection and neurologic disorders. Reducing the radiotracer dose could decrease the patient’s radiation exposure in PET imaging. However, it could also increase the noise and then affect the image quality. Researchers from the Shenzhen Institutes of
A pandemic can strike at any time. It takes little more than the right roll of genetic dice in a virus circulating among animals, followed by a chance encounter with a person or some go-between species, like pigs or mosquitoes. But as the new coronavirus whips around the world with a speed matched by few
The heart’s ability to beat normally over a lifetime is predicated on the synchronized work of proteins embedded in the cells of the heart muscle. Like a fleet of molecular motors that get turned on and off, these proteins cause the heart cells to contract, then force them to relax, beat after life-sustaining beat. Now
A minimally invasive procedure to treat a common foot and ankle disorder can reduce pain, recovery time, and postsurgery complications while improving functional outcomes, according to a report published in the journal Foot and Ankle Surgery. The procedure treats insertional Achilles tendinopathy, a common and chronic orthopedic disorder in which patients experience pain at the
A 2 degrees Celsius rise in temperatures could result in around 2,100 additional deaths from injuries every year in the United States. This is the finding of research from Imperial College London, Columbia University and Harvard University, published in the journal Nature Medicine. In the study, funded by the US Environmental Protection Agency and the
New research in the January 2020 issue of JNCCN—Journal of the National Comprehensive Cancer Network uses data from the National Health Interview Survey (NHIS) from 2000 to 2017 to examine self-reported drinking habits among people reporting a cancer diagnosis. The researchers found that of 34,080 survey participants, 56.5 percent were current drinkers, 34.9 percent exceeded
A newly published paper in PNAS details a research breakthrough that provides a promising starting point for scientists to create drugs that can cure C. diff—a virulent health care-associated infection that causes severe diarrhea, nausea, internal bleeding, and potentially death. The bacteria affects roughly half-a-million Americans and causes nearly 15,000 deaths in the U.S. annually.
A new approach to programing cancer-fighting immune cells called CAR-T cells can prolong their activity and increase their effectiveness against human cancer cells grown in the laboratory and in mice, according to a study by researchers at the Stanford University School of Medicine. The ability to circumvent the exhaustion that the genetically engineered cells often
Every year, more than 59,000 people around the world die of rabies and there remains no cheap and easy vaccine regimen to prevent the disease in humans. Now, researchers report in PLOS Neglected Tropical Diseases that adding a specific immune molecule to a rabies vaccine can boost its efficacy. Previous studies have suggested that the