Adipose tissue is not just a simple reservoir of energy for periods of food scarcity. It contributes significantly to regulation of the metabolism, releasing various molecules into the bloodstream, including microRNAs that modulate the expression of key genes in different parts of the organism, including the liver, pancreas, and muscles. Research has shown that both
Biomedical engineers at Duke University have discovered a pharmaceutical target that, when activated, can reverse bone degradation caused by osteoporosis in mouse models of the disease. “The most widely used drugs currently approved by the FDA to treat osteoporosis can prevent further bone loss, but they don’t help rebuild the bone,” said Shyni Varghese, professor
A heart attack triggers an acute inflammatory response, followed by resolution of inflammation and wound healing. A severe heart attack, however, can cause chronic and sustained inflammation that leads to heart failure and death. In mouse experiments, University of Alabama at Birmingham scientists now have shown a way to hit an immunological “reset button” that
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