Tag: strains

Xeno/endobiotic metabolism potencies vary between strains and sex in rats

Rats are commonly used in nonclinical pharmaceutical studies to investigate the safety, efficacy and pharmacokinetic profiles of drug candidates before they are entered into clinical studies. Most compounds administered via the oral route are metabolized in the liver and intestine, so the metabolism is a key determinant of pharmacokinetics. The uridine 5′-diphospho-glucuronosyltransferase (Ugt) superfamily is