A research team based at Tokyo Medical and Dental University (TMDU) has used an integrated data analysis to classify hepatocellular carcinoma, the most common type of liver cancer, into three distinct subgroups, which should aid targeted treatment Liver cancer remains a major problem in healthcare globally, being the second most common cause of cancer-related death
Single-cell sequencing technologies are filling in fine details in the catalog of life. Researchers at the University of Connecticut Health Center (UConn Health) and The Jackson Laboratory (JAX) have identified 40 subtypes of retinal ganglion cells (RGCs) along with the genetic markers and transcription factors that differentiate them. Thanks to recent advances in droplet-based single-cell
Cells have traditionally been categorized into different types, such as T-cells and B-cells, based on observable features. But new research published in Nature Communications shows cells are far more complex. Purdue University researchers created an algorithm called ACTION to group cells based on their primary function and pinpoint the genes responsible for those functions. They
Melanoma, a relatively rare but deadly skin cancer, has been shown to switch differentiation states—that is, to regress to an earlier stage of development—which can lead it to become resistant to treatment. Now, UCLA researchers have found that melanomas can be divided into four distinct subtypes according to their stages of differentiation. Cell subtypes that
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