Tag: tuberculosis

Insights into how harmful white blood cells form during tuberculosis infection point to novel targets for pharmacological interventions, according to a study published in the open-access journal PLOS Pathogens by Valentina Guerrini and Maria Laura Gennaro of Rutgers New Jersey Medical School, and colleagues. Foam cells are a type of white blood cell, known as

Tuberculosis is one of the world’s deadliest infectious disease. Worldwide, there are still about 10.4 million cases of TB and 1.7 million deaths every year. One of the reasons it’s been hard to bring the disease under control is that the drugs used to treat it require a gruelling regimen and can be toxic. This

Guided by glowing bacteria, researchers have devised an imaging technique that can diagnose live tuberculosis in an hour and help monitor the efficacy of treatments. That’s particularly critical because many TB strains have evolved defenses against standard treatments. Jianghong Rao, PhD, a professor of radiology at Stanford who led the work, says that speedy TB

Severe infections leading to hospitalizations during childhood are associated with lower school achievement in adolescence,reports a study in the July issue of The Pediatric Infectious Disease Journal (PIDJ). In the nationwide study of nearly 600,000 Danish children, higher numbers of hospitalizations for infections were associated with a reduced probability of completing ninth grade, as well

A new SLAS Discovery article available now for free ahead-of-print, offers perspective from researchers at Coyne Scientific (Atlanta, GA) about Clinical Trials in a Dish (CTiD), a novel strategy that bridges preclinical testing and clinical trials. The pharmaceutical industry is facing unprecedented challenges as the cost of developing new drugs reaches unsustainable levels, fueled in

The mechanism our immune cells use to clear bacterial infections like tuberculosis (TB) might also be implicated in Parkinson’s disease, according to a new collaborative study led by the Francis Crick Institute, Newcastle University and GSK. The findings, which will be published in The EMBO Journal, provide a possible explanation of the cause of Parkinson’s

Biomedical engineers have discovered an unlikely potential ally in the global fight against tuberculosis—an FDA-approved drug originally designed to treat cancer. Matrix metalloproteinases (MMPs) are naturally produced by animals to break down connective tissue for a wide array of biological processes such as wound repair, growth and tissue development. Many diseases, however, can hijack these