Tag: vaccine

Preclinical data for COVID-19 vaccine candidate show effectiveness and advantages

A COVID-19 vaccine candidate that underwent extensive preclinical testing at the University of Alabama at Birmingham this spring and summer shows potent preclinical immune responses—including several that distinguish it from other COVID-19 vaccine approaches—according to a preprint deposited in the BioRxiv repository this week. Partial preclinical results had been announced in July and August by

How changing vaccine schedules can save costs and lives: Findings from South Africa

In 2005, before most low- and middle-income countries started vaccinating children routinely for pneumococcal disease, it caused approximately 1.5 million deaths worldwide annually. About 700,000 to 1 million of these deaths were in children under five years. Pneumococcal disease occurs when Streptococcus pneumoniae invades a normally sterile area of the body, causing meningitis, pneumonia, septicaemia

Single-dose vaccine tested as US experts say no corners cut

A huge international study of a COVID-19 vaccine that aims to work with just one dose is getting underway as top U.S. health officials sought Wednesday to assure a skeptical Congress and public that they can trust any shots the government ultimately approves. Hopes are high that answers about at least one of several candidates

Ensuring an ethical path to a ‘warp speed’ vaccine

A vaccine for COVID-19 is seen by many—rightly or wrongly—as the finish line for the pandemic, the shot that will mark the resumption of our normal lives. Yet recent polls suggest that a significant fraction of Americans may opt not to get a vaccine when one becomes available, or are at least wary of getting

Global trial to test whether MMR vaccine protects front-line health-care workers against COVID-19

An international research network of physicians and scientists is launching a clinical trial to evaluate whether the vaccine for measles, mumps and rubella (MMR) can protect front-line health-care workers against infection from SARS-CoV-2, the virus that causes COVID-19. The trial aims to enroll up to 30,000 health-care workers globally. Washington University School of Medicine in

Virologists select SARS-CoV-2 vaccine candidate for clinical trials

Virologists at the Rega Institute at KU Leuven (Belgium) have developed a vaccine candidate that protects hamsters from infection with the SARS-CoV-2 coronavirus. Theirs is one of the first vaccine candidates that is proven to protect lab animals from infection. The team aims to start clinical trials next Winter. Their findings are pending peer review,

NIH ACTIV working group weighs human challenge studies for SARS-CoV-2 vaccine development

In a Perspective for the New England Journal of Medicine, members of the National Institutes of Health’s Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) Vaccines Working Group assess practical considerations and prerequisites for using controlled human infection models (CHIMs), which can be used for human challenge studies, to support SARS-CoV-2 vaccine development. In the article,

Brazil to help test Oxford coronavirus vaccine

An experimental vaccine against the new coronavirus developed at the University of Oxford will be tested from mid-June in Brazil, the first country outside Britain to take part in the study, researchers said Wednesday. The vaccine will be tested in Brazil on 2,000 volunteers, who will be recruited starting this week, said the Federal University

Monkeys, ferrets offer needed clues in COVID-19 vaccine race

The global race for a COVID-19 vaccine boils down to some critical questions: How much must the shots rev up someone’s immune system to really work? And could revving it the wrong way cause harm? Even as companies recruit tens of thousands of people for larger vaccine studies this summer, behind the scenes scientists still

Inroads to a better Ebola vaccine

As the world focuses on finding a COVID-19 vaccine, research continues on other potentially catastrophic pandemic diseases, including Ebola and Marburg viruses. The world cannot afford to take our eye of other threats, says Flinders University Professor Nikolai Petrovsky, who warns the highly lethal and infectious Ebola virus could appear in a more virulent form.

Germany warns vaccine could take ‘years’

Germany’s health minister said developing a vaccine for the coronavirus could take “years”, after Donald Trump predicted it could be achieved by the end of 2020. “I would be delighted if it was possible to achieve this in a few months,” Jens Spahn said late Sunday on ARD television. “But it can also take years

Scientists are already working on a coronavirus vaccine

Scientists are already working on a coronavirus vaccine – but warn it will likely be years before there is a shot to prevent the contagious illness which has so far killed 17 people A new coronavirus has sickened more than 500 people worldwide and killed 17 in China, where it originated  The first US case

Researchers develop a faster, stronger rabies vaccine

Every year, more than 59,000 people around the world die of rabies and there remains no cheap and easy vaccine regimen to prevent the disease in humans. Now, researchers report in PLOS Neglected Tropical Diseases that adding a specific immune molecule to a rabies vaccine can boost its efficacy. Previous studies have suggested that the