Tag: Drug

Diabetes drug relieves nicotine withdrawal

A drug commonly used to treat Type II diabetes abolishes the characteristic signs of nicotine withdrawal in rats and mice, according to new research published in JNeurosci. The finding may offer an important new strategy in the battle to quit smoking. Smokers trying to quit face potent side effects from nicotine withdrawal, including cravings, increased

Competitive people are more prone to drug consumption

Hostile and competitive people are more likely to give in to drug consumption, according to a study published by a research group at the University of Cordoba (Spain). When a person faces a decision regarding these kinds of substances, multiple factors come into play, such as social environment, family history and past experiences. Now, this

Researchers discover potential drug to treat heart attacks

A potential drug to treat heart attacks and to prevent heart failure—for which no cure currently exists—may result from pioneering research by a University of Guelph professor. Prof. Tami Martino, Department of Biomedical Sciences, and Ph.D. student Cristine Reitz have discovered what they believe is a novel drug target controlling the body’s repair responses after

Drug discovery offers new hope to halt the spread of malaria

Breakthrough research has revealed a new drug that may prevent the spread of malaria, and also treat people suffering with the deadly parasitic disease. The findings, which were delivered by an international team of scientists led by the University of Glasgow and published today in Science, offer fresh hope in the global fight against malaria.

3-D miniature livers lead the way to patient-specific drug discovery

The human liver is a vital organ involved in multiple functions. Because susceptibility to liver diseases is highly variable among patients, researchers from Tokyo Medical and Dental University (TMDU) and Cincinnati Children’s Hospital Medical Center (CCHMC) have engineered a model liver system that can be personalized for disease modeling and drug discovery. In a study

Alzheimer’s drug trial targets by-product of gum disease

The pharmaceutical company, Cortexyme, Inc. has outlined a trial of potential Alzheimer’s drug that targets toxic substances released by P. gingivalis, a bacteria linked to gum disease. In a poster presented at the Alzheimer’s Association International Conference today (Wednesday, July 17), researchers provided an overview of the development of the drug, known as COR388, and

New drug could help treat neonatal seizures

A new drug that inhibits neonatal seizures in rodent models could open up new avenues for the treatment of epilepsy in human newborns. Researchers have identified that gluconate—a small organic compound found in fruit and honey—acts as an anticonvulsant, inhibiting seizures by targeting the activity of channels that control the flow of chloride ions in

Rheumatoid arthritis drug diminishes Zika birth defects in mice

In experiments with pregnant mice infected with the Zika virus, Johns Hopkins Medicine researchers report they have successfully used a long-standing immunosuppressive drug to diminish the rate of fetal deaths and birth defects in the mice’s offspring. The U.S. Food and Drug Administration-approved medicine, anakinra, once commonly used to treat rheumatoid arthritis and other autoimmune

New drug could help those with tough-to-treat cholesterol

People whose high cholesterol is resistant to treatment with statin drugs may soon have a new treatment option. This new class of drugs helps block synthesis of artery-clogging cholesterol, researchers explained. The drugs target an enzyme called ATP citrate lyase (ACL), part of the production pathway for “bad” LDL cholesterol in the body. In the

Gonorrhoea: Drug resistance compromises recommended treatment in Europe

Gonorrhoea is the second most commonly notified sexually transmitted infection across the EU/EEA countries with almost 500 000 reported cases between 2007 and 2016. The infection is treatable but Neisseria gonorrhoeae keep showing high levels of azithromycin resistance according to latest results of the European Gonococcal Antimicrobial Surveillance Programme. This antibiotic agent is part of

Cancer has a biological clock and this drug may keep it from ticking

A new drug shows potential to halt cancer cells’ growth by stunting the cells’ biological clock. The findings from scientists at the USC Michelson Center for Convergent Bioscience and Nagoya University’s Institute of Transformative BioMolecules (ITbM) advance a burgeoning area of research: turning the body’s circadian rhythms against cancer. Their study, conducted on human kidney

Catheter ablation superior to standard drug therapy for heart failure

A meta-analysis of randomized controlled trials found that catheter ablation was superior to conventional drug therapy alone for patients with atrial fibrillation and heart failure. Findings are published in Annals of Internal Medicine. Atrial fibrillation is associated with thromboembolic stroke, systemic embolism, and decompensated heart failure. Catheter ablation is an established therapeutic strategy for atrial

Experimental Alzheimer’s drug improves memory in mice

An experimental drug known as A03, which was previously developed to treat depression, increases the levels of the enzyme Sirtuin1, or SirT1, and improves memory in mice. The mice were genetically modified to have a protein called ApoE4, the most common genetic risk factor for Alzheimer’s disease in humans that has been linked to some