Tag: Colon Cancer

Childhood cancer: The four survival strategies of tumor cells

Cancer cells in children tend to develop by following four main trajectories — and two of them are linked to relapse of the disease, research led by Lund University in Sweden shows. The four strategies can occur simultaneously in a single tumour, according to the study that is now published in Nature Genetics. The researchers

Cancer cells co-opt pain-sensing ‘wasabi receptor’ to survive oxidative stress: Antioxidants and the TRPA1 channel protein complement each other to increase tumor survival

Anyone who’s taken a bite of a sandwich with too much spicy mustard or a piece of sushi with too much wasabi can attest to the tear-inducing sensation these condiments can cause. These loud warnings to the nervous system of exposure to potentially harmful chemicals are triggered by TRPA1, a calcium channel protein sometimes referred

For mothers with advanced cancer, parenting concerns affect emotional well-being

Parenting concerns contributed significantly to the psychological distress of mothers with late-stage cancer, according to a study by University of North Carolina Lineberger Comprehensive Cancer Center researchers. Cancer is the leading cause of disease-specific death for parenting-age women in the United States, and women with incurable cancer who have children can have increased rates of

Using mathematical modeling and evolutionary principles important in treatment decisions: Moffitt researchers show continuous maximum dose and adaptive treatment approaches are effective strategies for different tumors

Cancer patients are commonly treated with the maximum dose they are able to withstand that does not cause too many toxic side effects. However, many patients become resistant to these treatments and develop cancer recurrence. Researchers at Moffitt Cancer Center are using mathematical modeling based on evolutionary principles to show that adaptive drug treatments based

New approach to treating patients with stage IV Wilms tumor: Four-year overall survival increased 12 percent for patients with stage IV Wilms tumor with lung metastases

A new study showing significantly improved survival rates for patients with stage IV Wilms tumors with lung metastases was recently published in the Journal of Clinical Oncology. The outcomes of the study, “Treatment of Stage IV Favorable Histology Wilms Tumor With Lung Metastases: A Report From the Children’s Oncology Group AREN0533 Study,” will be a

In-depth genomic analysis of 33 cancer types

Researchers funded by the National Institutes of Health have completed a detailed genomic analysis, known as the PanCancer Atlas, on a data set of molecular and clinical information from over 10,000 tumors representing 33 types of cancer. “This project is the culmination of more than a decade of groundbreaking work,” said NIH Director Francis S.

In-depth genomic analysis of 33 cancer types

Researchers funded by the National Institutes of Health have completed a detailed genomic analysis, known as the PanCancer Atlas, on a data set of molecular and clinical information from over 10,000 tumors representing 33 types of cancer. “This project is the culmination of more than a decade of groundbreaking work,” said NIH Director Francis S.

New trigger for onset of colon cancer: May lead to better therapies

Colon cancer is the second most common cause of cancer-related deaths. The APC protein has long been known for its critical role in preventing colorectal cancer. When APC is inactivated, the development of colorectal cancer is triggered. Inactivation of APC is responsible for the vast majority (80%) of all colorectal cancers. Researchers from the laboratory