Tag: discover

Leading scientists at the University of Birmingham have discovered a previously unknown pathway that prevents specific drugs from working in patients with bowel cancer. The research findings pave the way for increasing the number of bowel cancer patients who can be successfully treated, say the scientists. Bowel cancer, also called colorectal cancer, affects the large

Glioblastomas are the most common and most aggressive brain tumors. Their survival rate has barely increased over the last 50 years, indicating an urgent need to develop new therapeutic strategies. In a paper published this week in the journal Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research, the team led by

Researchers from the University of Missouri School of Medicine have discovered a treatment combination that significantly reduces tumor growth and extends the life span of mice with liver cancer. This discovery provides a potentially new therapeutic approach to treating one of the leading causes of cancer-related death worldwide. A cancer translational research team consisting of

Recently, a research team led by Profs. Liu Qingsong and Liu Jing from the Institute of Health & Medical Technology of the Hefei Institutes of Physical Science (HFIPS) discovered a potent and selective PI3Kδ inhibitor IHMT-PI3Kδ-372, effective against chronic obstructive pulmonary disease (COPD) in vivo. COPD is a chronic progressive respiratory disease characterized by airflow

Researchers at the University of São Paulo (USP) in Brazil have discovered that the muscle regeneration promoted by aerobic exercise is mediated by changes in oxygen consumption by satellite cells, also known as skeletal muscle stem cells. The discovery is expected to be used to help people recover from injury and combat the loss of

In breakthrough colon cancer research, scientists at ChristianaCare’s Helen F. Graham Cancer Center & Research Institute have discovered a link between two key signaling pathways crucial to the development and growth of colon cancer. The study is published today in the journal PLOS ONE. The scientists identified the link between the retinoic acid or RA

Researchers at the Netherlands Cancer Institute have discovered salivary glands in a previously unknown location. This is potentially great news for patients with head and neck tumors: Radiation oncologists will now be able to circumvent this area to avoid potential complications. The research is forthcoming in Radiotherapy & Oncology. Advanced technology allows scientists to visualize

New research has uncovered the previously unknown presence of CD19—a B cell molecule targeted by chimeric antigen receptor (CAR) T cell immunotherapy to treat leukemia, lymphoma, and multiple myeloma—in brain cells that protect the blood brain barrier (BBB). This discovery may potentially be the cause for neurotoxicity in patients undergoing CD19 directed CAR T cell

Scientist Mary Rodgers spends her days tracking killers—elusive, constantly mutating viruses that travel the globe and are responsible for illness or death in millions of people. Wednesday, in an article published in the Journal of Acquired Immune Deficiency Syndromes, Rodgers and her team at Abbott, along with co-authors at the University of Missouri, announced their

Researchers at The Ohio State University Comprehensive Cancer Center—Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC—James) report a discovery that helps scientists understand why some tumors lack immune cell infiltration and are therefore unresponsive to newer PD-1 targeted therapies. PD-1 is a checkpoint protein on T cells, a type of immune

Is THIS what causes mysterious polio-like illness in kids? Scientists discover signs that a common cold virus may trigger life-threatening paralysis in children Since 2014, nearly 600 people – mostly young children – have been diagnosed with acute flaccid myelitis   The mysterious polio-like condition has left young children with mysterious paralysis that becomes life-threatening for some

A potential drug to treat heart attacks and to prevent heart failure—for which no cure currently exists—may result from pioneering research by a University of Guelph professor. Prof. Tami Martino, Department of Biomedical Sciences, and Ph.D. student Cristine Reitz have discovered what they believe is a novel drug target controlling the body’s repair responses after

Scientists discover a hunger ‘switchboard’ in the brain – and may soon be able to turn your appetite ‘on’ or ‘off’ Researchers at the University of Arizona discovered a complex network of brain regions that communicate to tell us when we are hungry or sated They found that they could use chemicals to turn ‘off’

New research has found it is not just what you eat, but when you eat that is important, knowledge which could improve the health of shift workers and people suffering from jet lag. The Medical Research Council (MRC)-funded study, published today in the journal Cell, is the first to identify insulin as a primary signal

‘Revolutionary’ treatment may prevent blindness: Scientists discover way of boosting stem cells’ healing properties after eye injuries and acid attacks Stem cells in the cornea work less effectively after serious injury to the eye They are needed to heal wounds and therefore prevent sight loss  Scientists discovered how to improve this function after injury using

How to retrain your brain to say ‘no’ to overeating: Scientists discover neurons that make us ‘forget’ we want food More than two thirds of American adults are overweight or obese   Some 45 million people go on a diet every year in the US  But just restricting calories is not enough to keep off weight

Researchers have identified a biomarker and a possible new therapy for melanoma. Microphthalmia-associated transcription factor (MITF) is a protein that plays a pivotal role in the maintenance of the melanocyte (cells that make melanin) lineage, differentiation of normal and malignant melanocytes and the survival of melanoma cells. “We have now detected the first useful chemical

It was the diet du jour of the noughties, as popularised by the Paleo diet, the broscience diet, Atkins v2.0 and the Dukan diet. Carbs were out of fashion so we needed something to replace them with. Besides, high protein diets left people feeling full for longer and, some studies showed, they led to greater

Hope for epileptics as scientists discover implanting stem cells into the brain could stop seizures The treatment, tested on rats, would modify the patient’s own skin cells Stem cell treatment led to 70% fewer seizures in the months following It inhibits excitement in the hippocampus, where epileptic seizures can start  Currently, surgery to remove the hippocampus

USC researchers seeking a way to study genetic activity associated with psychiatric disorders have discovered an abundant source of human cells—the nose. Olfactory epithelial cells, easily collected from the lining of the nasal cavity, can serve as stand-ins for brain cells in studies of the neuronal epigenome, USC researchers say. The epigenome is a system