Tag: factor

Cell stress mechanisms identified as prognostic factor for chronic inflammatory liver disease

Primary sclerosing cholangitis (PSC) is a rare chronic inflammatory disease of the bile ducts and is difficult to treat, since its causes have not yet been adequately researched. Using RNA sequencing, an international research consortium led by Michael Trauner, Head of MedUni Vienna’s Division of Gastroenterology and Hepatology (Department of Medicine III), has now identified

Scientists identify new genetic MND risk factor in junk DNA

A new genetic risk factor for Motor Neurone Disease (MND), which if treated could halt or prevent the degenerative condition, has been identified in so-called ‘junk DNA’ by scientists at the University of Sheffield. The newly discovered genetic changes are present in up to one percent of MND patients. The pioneering research, published in the

MANF identified as a rejuvenating factor in parabiosis

Older mice who are surgically joined with young mice in order to share a common bloodstream get stronger and healthier, making parabiosis one of the hottest topics in age research. Publishing in Nature Metabolism, researchers from the Buck Institute report that MANF (mesencephalic astrocyte-derived neurotrophic factor) is one of the factors responsible for rejuvenating the

Have researchers found a new risk factor for schizophrenia?

Schizophrenia, a condition characterized by a confused perception of reality, delusions, and altered behavior, affects more than 21 million people globally. In a new study, specialists from Johns Hopkins Medicine in Baltimore, MD, and the Sheppard Pratt Health System in Townson, MD, found evidence that links schizophrenia with the Epstein-Barr virus. This is a herpes

Post-stroke delivery of neurotrophic factor MANF promotes functional recovery in rats

Stroke is the most common cause of adult disability. This is due not only to the high incidence of stroke, but also because spontaneous recovery is often incomplete and no drugs are available that hasten recovery. Mesencephalic astrocyte-derived neurotrophic factor MANF is neuroprotective when administered before experimental stroke in rats. A massive immune response mediated