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Fast-tracking drug development for neurodegenerative disorders

A Griffith University-led research team has discovered how a therapeutic target common among debilitating neurodegenerative disorders is activated, which could help accelerate drug development. In a study published in the journal Neuron, the researchers from Griffith University’s Institute for Glycomics, the University of Queensland and Washington University, analyzed the structure and function of a protein

Researchers find effective combination of therapies for managing mitochondrial disease

Researchers from the Mitochondrial Medicine Frontier Program at Children’s Hospital of Philadelphia (CHOP) have demonstrated how one combination of therapies may be beneficial for patients with mitochondrial respiratory chain disorders. This preclinical research paves the way to develop more tailored treatment options for patients with inherited mitochondrial disease and acquired energy disorders. The findings emphasize

A new theory for how memories are stored in the brain

Research from the University of Kent has led to the development of the MeshCODE theory, a revolutionary new theory for understanding brain and memory function. This discovery may be the beginning of a new understanding of brain function and in treating brain diseases such as Alzheimer’s. In a paper published by Frontiers in Molecular Neuroscience,

Research points to new hope for treatment-resistant age-related macular degeneration

An oxysterol that accumulates in the eye with age can transform choroidal endothelial cells; interfering with the process might help patients with treatment-resistant age-related macular degeneration. The latest research from the laboratory of John A. Moran Eye Center physician-scientist Mary Elizabeth Hartnett, MD, reveals how an oxidized form of cholesterol can change choroidal endothelial cells

Single dose of Pfizer BioNTech vaccine reduces asymptomatic infections and potential for SARS-CoV-2 transmission

New data from Addenbrooke’s Hospital in Cambridge suggests that a single dose of the Pfizer BioNTech vaccine can reduce by four-fold the number of asymptomatic SARS-CoV-2 infections. This implies that the vaccine could significantly reduce the risk of transmission of the virus from people who are asymptomatic, as well as protecting others from getting ill.

Americans less worried about dying from COVID-19 as support for vaccine mandate grows

In a new ongoing panel survey by Northwestern University and The Ohio State University, researchers find Americans significantly less concerned they could die of COVID-19, while their overall perceived likelihood of contracting the virus remained relatively consistent from December through February. “Public Attitudes about COVID-19 Vaccination,” a study of 1,200 Americans surveyed monthly from December

Medications for enlarged prostate linked to heart failure risk

Widely used medications for benign prostatic hyperplasia (BPH)—also known as enlarged prostate—may be associated with a small, but significant increase in the probability of developing heart failure, suggests a study in The Journal of Urology, Official Journal of the American Urological Association (AUA). The risk is highest in men taking a type of BPH medication

Improved vectors for ocular gene therapy

Strategies based on the use of gene therapy to mitigate the effects of mutations that cause blindness are undergoing rapid development. Novel gene vectors now achieve widespread gene delivery and reduce the risks associated with these approaches. The incidence of genetic mutations that result in rapid deterioration of the ability to see is larger than

Tirbanibulin superior to placebo for actinic keratosis

(HealthDay)—Tirbanibulin is superior to vehicle at two months for the treatment of actinic keratosis, but almost half of patients who had a complete response experienced recurrence of lesions at one year, according to a study published in the Feb. 11 issue of the New England Journal of Medicine. Andrew Blauvelt, M.D., from the Oregon Medical

Serbia says it’s ready for Russian vaccine production

Serbia is ready to domestically produce the Russian Sputnik V vaccine after successfully using it and a Chinese-developed shot in its inoculation campaign, officials said Thursday. A team of Russian experts arrived in Serbia on Thursday to evaluate technical details of the arrangement, which many see as another Serbian step away from a proclaimed goal

Scientists use knowledge from climate system modeling to develop global prediction system for COVID-19 pandemic

At the time of writing, coronavirus disease 2019 (COVID-19) is seriously threatening human lives and health throughout the world. Before effective vaccines and specific drugs are developed, non-pharmacological interventions and numerical model predictions are essential. To this end, a group led by Professor Jianping Huang from Lanzhou University, China, developed the Global Prediction System of

Anticancer drug may improve outcome for severe COVID-19 patients

Treating severe COVID-19 patients with the anticancer drug bevacizumab may reduce mortality and speed up recovery, according to a small clinical study in Italy and China that was led by researchers at Karolinska Institutet in Sweden between February and April 2020. On average, blood oxygen levels, body temperature and inflammatory markers significantly improved in patients