Tag: Human Biology

New cardiac fibrosis study identifies key proteins that translate into heart disease

Using cutting-edge technologies, researchers at Duke-NUS Medical School, Singapore, have developed the first genome-wide dataset on protein translation during fibroblast activation, revealing a network of RNA-binding proteins (RBPs) that play a key role in the formation of disease-causing fibrous tissue in the heart. Their findings, published in the journal Circulation, could help in the search

Take a bath 90 minutes before bedtime to get better sleep

Biomedical engineers at The University of Texas at Austin may have found a way for people to get better shuteye. Systematic review protocols — a method used to search for and analyze relevant data — allowed researchers to analyze thousands of studies linking water-based passive body heating, or bathing and showering with warm/hot water, with

Helping transplanted stem cells stick around and do their jobs: New microgel encapsulation method paves the way for more efficient cell therapies

Bone marrow transplants of hematopoietic stem cells have become standard treatment for a host of conditions including cancers of the blood and lymphatic systems, sickle cell anemia, inherited metabolic disorders, and radiation damage. Unfortunately, many bone marrow transplants fail due to rejection by the patient’s immune system or graft-versus-host disease (in which the transplanted marrow

New method for engineering metabolic pathways: Two approaches provide faster way to create complex molecules

Cells are incredibly adept at creating complex molecules, like therapeutics, and can do so much better than many of our best factories. Synthetic biologists look to re-engineer cells to make these molecules for specific needs, including pharmaceuticals and energy applications. But the trial-and-error process is difficult and time-consuming, and often competes with the cell’s other

Massive sequencing study links rare DNA alterations to type 2 diabetes: Scientists identify new genetic targets for disease research and potentially drug development

An international consortium of scientists has analyzed protein-coding genes from nearly 46,000 people, linking rare DNA alterations to type 2 diabetes. The study, one of the largest known of its type, includes data from people of European, African American, Hispanic/Latino, East Asian, and South Asian ancestries. From this large cohort — roughly 21,000 individuals with

The history of humanity in your face

The face you see in the mirror is the result of millions of years of evolution and reflects the most distinctive features that we use to identify and recognize each other, molded by our need to eat, breath, see, and communicate. But how did the modern human face evolve to look the way it does?

Breakthrough in knowledge of how some sarcomas arise

The origin of certain cancers in the sarcoma group is associated with a hitherto unknown interaction among different proteins. Findings now being presented create the opportunity to test new treatments of these forms of sarcoma. “We now know which mechanisms to shine the spotlight on,” says Pierre Åman, Professor of Tumor Biology at Sahlgrenska Academy,

‘Master pacemaker’ for biological clocks identified

What makes a biological clock tick? According to a new study from U of T Mississauga, the surprising answer lies with a gene typically associated with stem and cancer cells. In the first study of its kind for the field of circadian biology, UTM researchers used RNA sequencing to observe the expression of genes in

Uncovering uncultivated microbes in the human gut: Human gut microbiome serves as model to demonstrate efficacy of computational tools

A tree’s growth is dependent on nutrients from the soil and water, as well as the microbes in, on, and around the roots. Similarly, a human’s health is shaped both by environmental factors and the body’s interactions with the microbiome, particularly in the gut. Genome sequences are critical for characterizing individual microbes and understanding their

Whopping big viruses prey on human gut bacteria: Largest phages ever found in humans target bacteria associated with hunter-gatherer diets

Viruses plague bacteria just as viruses like influenza plague humans. Some of the largest of these so-called bacteriophages have now been found in the human gut, where they periodically devastate bacteria just as seasonal outbreaks of flu lay humans low, according to a new study led by University of California, Berkeley, scientists. These “megaphages” —

Herpes viruses and tumors evolved to learn how to manipulate the same ancient RNA: Findings could have implications for drugs and insight into diseases like Alzheimer’s

Herpes viral infections use the ancient genetic material found in the human genome to proliferate, mimicking the same process tumors have been found to manipulate, Mount Sinai researchers have shown for the first time. These observations provide further insight about how herpes viruses can manipulate the immune system in ways that may drive neurodegenerative diseases

Ebola-fighting protein discovered in human cells: Drug that mimics function of protein could one day become an effective therapy to fight Ebola virus

Researchers have discovered a human protein that helps fight the Ebola virus and could one day lead to an effective therapy against the deadly disease, according to a new Northwestern Medicine study. The newly discovered ability of the human protein RBBP6 to interfere with Ebola virus replication suggests new ways to fight the infection. As