Tag: immune

Researchers identify immune cells that contribute to transplant rejection

Non-circulating memory T cells, whose main function is to provide local protection against re-infection, contribute to chronic transplant rejection, University of Pittsburgh School of Medicine researchers reveal in a paper published today in Science Immunology. The scientists show that these “tissue-resident memory T cells” are harmful in situations where antigens that the cells recognize are

Research shows how mutations in SARS-CoV-2 allow the virus to dodge immune defenses

The vast majority of people infected with SARS-CoV-2 clear the virus, but those with compromised immunity—such as individuals receiving immune-suppressive drugs for autoimmune diseases—can become chronically infected. As a result, their weakened immune defenses continue to attack the virus without being able to eradicate it fully. This physiological tug-of-war between human host and pathogen offers

How a receptor shapes the immune response

Researchers led by Professor Carolyn King of the University of Basel have developed a method to study the specialization of T cells in the context of infections. In the journal eLife, they report the different directions this specialization takes, depending on whether it happens in the context of an acute viral infection such as influenza

Eat These 5 Foods to Support Your Immune System

Vitamins and supplements are highly useful tools for a lot of folks looking for some immune system support through cold and flu season and beyond. But they are just that—tools. They are not a foolproof solution to stay healthy. The best way to achieve that goal, and support a strong immune system, is by packing

Immune system protects children from severe COVID-19

Children are protected from severe COVID-19 because their innate immune system is quick to attack the virus, a new study has found. The research led by the Murdoch Children’s Research Institute (MCRI) and published in Nature Communications, found that specialized cells in a child’s immune system rapidly target the new coronavirus (SARS-CoV-2). MCRI’s Dr. Melanie

Tissue stiffness likely drives immune responses in many chronic diseases

Stiffness in our tissues causes tension in our cells. Research from the Buck Institute, the University Health Network (University of Toronto), Stanford University, and the University of Alberta shows that stiffness impacts the innate immune system by upping its metabolism. The findings suggest the cellular tension likely sets off an inflammatory loop that contributes to

A new way to help the immune system fight back against cancer

Scientists at the University of Wisconsin School of Medicine and Public Health are breaking new ground to make cancer cells more susceptible to attack by the body’s own immune system. Working in mice, a team led by Jamey Weichert, professor of radiology, and Zachary Morris, professor of human oncology, is combining two different techniques in

Helping the immune system to combat cancer

Cancers sometimes escape our immune defenses because of the over-activity of molecular signaling systems, called checkpoint processes. Now we may be able to fight back using a new range of molecules, researchers in China report in the European Journal of Medicinal Chemistry. “We have been working on the discovery of anti-cancer agents for more than

How the immune system deals with the gut’s plethora of microbes

The gut is an unusually noisy place, where hundreds of species of bacteria live alongside whatever microbes happen to have hitched a ride in on your lunch. Scientists have long suspected that the gut’s immune system, in the face of so many stimuli, takes an uncharacteristically blunt approach to population control and protection from foreign

TLK protein inhibition activates the innate immune system

Tousled-like kinases (TLKs) are a potential therapeutic target for cancer treatment due to their central role in DNA repair and replication. The latest work by IRB Barcelona’s Genomic Instability and Cancer Laboratory, led by Travis H. Stracker, concludes that TLK inhibition activates the innate immune system, a very important factor in the response to cancer.

Researchers identify possible immune targets in the SARS-CoV-2 genome

Otago researchers studying the COVID-19 virus (SARS-2) have discovered potential target points on its genome, which may contribute to future treatments for the virus. While their laboratory was locked down during the Level 4 period, Ph.D. student Ali Hosseini and Professor Alex McLellan from the Department of Microbiology and Immunology worked from their homes to

Missing component of innate immune signaling identified

How cells recognize pathogens and alert the immune system swiftly is a fundamental process of high importance for the survival of any species, including humans. A key role is ascribed to so-called adapters—little molecular platforms inside cells where signals from pathogen detectors are integrated for safety and accuracy and conveyed to lasting signals leading to

Immune ‘checkpoint switch-off’ enables destruction of cancer cells

A collaboration between the Griffith Institute for Drug Discovery (GRIDD) and multiple clinical research institutes has led to an exciting discovery in cancer research. The multi-disciplinary team, led by GRIDD’s Dr. Alexandre Cristino and Professor Maher Gandhi from Mater Research and including researchers from the Translational Research Institute, discovered a new mechanism in which the