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Zika virus’ key into brain cells ID’d, leveraged to block infection and kill cancer cells

Zika virus infection can stunt neonatal brain development, a condition known as microcephaly, in which babies are born with abnormally small heads. To determine how best to prevent and treat the viral infection, scientists first need to understand how the pathogen gets inside brain cells. Employing different approaches to answer different questions, two research teams

New study sheds light into origins of neurodegenerative disease

New research has shed light on the origins of spinocerebellar ataxia type 7 (SCA7) and demonstrates effective new therapeutic pathways for SCA7 and the more than 40 other types of spinocerebellar ataxia. The study, which appears online Monday on the website of the journal Neuron, implicates metabolic dysregulation leading to altered calcium homeostasis in neurons

Zooming into cilia sheds light into blinding diseases

A new study published today by researchers from Baylor College of Medicine and UT Health’s McGovern Medical School in the Proceedings of the National Academy of Sciences reveals an unprecedented close-up view of cilia linked to blindness. Cilia are short hair-like structures found on the surface of certain cells. They are particularly important in vision

Cycles of reward: New insight into ADHD treatment

Attention-deficit hyperactivity disorder (ADHD) is a widespread condition with complex underlying causes. A stimulant drug called methylphenidate is a common ADHD treatment that impacts the brain’s levels of dopamine, a neurotransmitter involved in systems of reward; however, methylphenidate has a potential for abuse, and its therapeutic effects are poorly understood. To explore methylphenidate’s varied interactions

Direct relationship between depression and inflammation called into question

Depression has traditionally been linked to increased inflammation. Innovative research by psychologist Eiko Fried refutes this popular assumption. He shows that specific depression symptoms such as sleeping problems explain this relationship. Publication in Psychological Medicine . Over the past few decades, there have been many studies into the relationship between depression and inflammation in the

First lung map uncovers new insights into asthma

For the first time, researchers have mapped the building blocks of the human lungs and airways, in both asthma patients and normal people. The research from the Wellcome Sanger Institute, University Medical Center Groningen, Open Targets, GSK and collaborators revealed the identity of each cell type, creating the first draft Human Cell Atlas of the