Tag: lung

For the first time, researchers have mapped the building blocks of the human lungs and airways, in both asthma patients and normal people. The research from the Wellcome Sanger Institute, University Medical Center Groningen, Open Targets, GSK and collaborators revealed the identity of each cell type, creating the first draft Human Cell Atlas of the

Results from a study published in the Journal of the National Medical Association show that a pragmatic system-based intervention within cancer treatment centers can nearly eliminate existing disparities in treatment and outcomes for black patients with early-stage lung and breast cancer. The treatment completion rates before this intervention were 87.3 percent for white patients versus

A new method of determining the sequence of molecules in DNA can be used to detect small fragments of cancerous genetic material in blood samples from lung cancer patients with a high degree of accuracy, according to new research published in the leading cancer journal Annals of Oncology today. Results from analyses of so-called “liquid

An approved drug normally used to treat fungal infections could also do the job of a protein channel that is missing in the lungs of people with cystic fibrosis, operating as a prosthesis on the molecular scale, says new research from the University of Illinois and the University of Iowa. Cystic fibrosis is a lifelong

Immune cells called T cells are key components in the fight against cancer. However, they sometimes struggle to recognize cancerous cells or to launch an appropriate response against them. T cell activity can be tweaked to improve anticancer effects using cancer immunotherapy, but this is only effective for a subset of patients, who are difficult

New strides are being made toward the ex vivo growth of human lungs. In a new article published in Tissue Engineering, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers, researchers report the development of a high-throughput, automated, multichannel lung bioreactor that allows parallel culture of up to five human cell-populated isolated rat lung scaffolds.

Woman, 68, who received a lung transplant develops her donor’s peanut allergy in ‘very rare’ phenomenon The unnamed patient, from San Diego, had never had a reaction to nuts before When doctors heard a sandwich triggered her symptoms they were suspicious Nut allergies are only believed to have been passed on four or five times

In an article published online by Frontiers in Endocrinology, researchers at the Medical University of South Carolina (MUSC) report that they have identified a potential therapeutic target for lung fibrosis or scarring. They showed in a preclinical model that the protein promotes fibrosis by turning on profibrotic genes and increasing levels of profibrotic factors, including

In an American Journal of Transplantation study, lung cancer risk was increased after lung transplantation, especially in the native (non-transplanted) lung of single lung transplant recipients. This was a large registry-linkage study that utilized matched transplant and cancer registry data from 17 US states/regions, including approximately 50 percent of US transplant recipients from 1987-2012. Researchers

The CRISPR-Cas9 gene editing system may be able to restore the effectiveness of first-line chemotherapies used to treat lung cancer by deleting or “knocking out” a gene in cancer tumors that helps the tumors develop resistance to the drugs. That was the conclusion of a new study published today in the journal Molecular Therapy Oncolytics

Pulmonary-renal syndrome (PRS) refers to a group of rare but potentially fatal conditions that nearly always are caused by a misguided attack by the body’s immune system on the lungs and kidneys. Coughing up blood and blood in the urine are telltale signs. Treatment with corticosteroids and immunosuppressant drugs can be effective if begun before

A combination of two drugs, which prompt the body’s immune system to identify and kill cancer cells, is a safe treatment for patients with advanced non-small cell lung cancer and has shown some signs of efficacy. Results from a phase I/II clinical trial in 25 patients, presented at the 30th EORTC-NCI-AACR Symposium on Molecular Targets

The majority of patients with cystic fibrosis may not achieve blood concentrations of antibiotics sufficiently high enough to effectively fight bacteria responsible for pulmonary exacerbations, leading to worsening pulmonary function, indicates a study led by researchers at Children’s National Health System. Additionally, the study findings show that it’s impossible to predict solely from dosing regimens

Researchers have developed a new nuclear medicine tracer that could improve diagnosis and treatment of non-small cell lung cancer. Research published in the November issue of The Journal of Nuclear Medicine found that the new tracer, 99mTc-HYNIC-cMBP, produced clearer images in less time than currently used tracers and was more rapidly eliminated from the body,

(HealthDay)—Profiles of childhood respiratory risk factors predict middle-age lung function levels and chronic obstructive pulmonary disease (COPD) risk, according to a study published in the September issue of the Annals of the American Thoracic Society. Dinh S. Bui, from the University of Melbourne in Australia, and colleagues assessed 11 childhood risk factor profiles (documented at

Cancer treatment continues to improve for many types of cancer, leading to increased life expectancy for many survivors. In fact, the number of cancer survivors is expected to reach nearly 18 million within the next decade in the U.S.1 For survivors of non-small cell lung cancer (NSCLC), the most common type of lung cancer, their

Persistent lung inflammation may be one possible explanation for why having asthma during childhood increases your risk for developing anxiety later in life, according to Penn State researchers. In a study with mice, researchers found that childhood exposure to allergens was linked with persistent lung inflammation. It was also connected to changes in gene expression

Patients using inhaled steroids to control asthma and other breathing problems may be at greater risk for developing nontuberculous mycobacteria (NTM) lung infections, according to new research published online in the Annals of the American Thoracic Society. NTM are in the same family as tuberculosis, but NTM come in many different species and are widely

TUESDAY, Aug. 28, 2018 — The quality of shared decision-making (SDM) about the initiation of lung cancer screening (LCS) is poor, according to a study published online Aug. 13 in JAMA Internal Medicine. Alison T. Brenner, Ph.D., M.P.H., from the University of North Carolina at Chapel Hill, and colleagues conducted a qualitative content analysis of

A four-protein biomarker blood test improves lung cancer risk assessment over existing guidelines that rely solely upon smoking history, capturing risk for people who have ever smoked, not only for heavy smokers, an international research team reports in JAMA Oncology. “This simple blood test demonstrates the potential of biomarker-based risk assessment to improve eligibility criteria