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Researchers of Hokkaido University, the National Agriculture and Food Research Organization (NARO), and Tohoku University demonstrated that a physiologically active substance called prostaglandin E2 (PGE2) impairs the immune response by upregulating the expression of an immunoinhibitory molecule, programmed death-ligand 1 (PD-L1), in cattle affected with Johne’s disease. The discovery is expected to help develop a

A team of researchers led by Brown University infectious disease experts and engineers has identified a new class of antibiotics that could one day help combat the alarming emergence of drug-resistant “superbugs.” Eleftherios Mylonakis, a professor of infectious diseases at Brown’s Warren Alpert Medical School and chief of infectious diseases at Rhode Island Hospital and

(HealthDay)—The office-based, eight-item Montreal Parkinson Risk of Dementia Scale is a valid predictor of development of dementia, according to a study published online March 26 in JAMA Neurology. Benjamin K. Dawson, from McGill University in Montreal, and colleagues conducted a multicenter study using four diverse Parkinson’s disease cohorts with a prospective 4.4-year follow-up to examine