Tag: progression

A research team led by the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) has built the first cellular model to depict the evolution of acute myeloid leukemia (AML), from its early to late stages. By using gene editing technologies to alter genes that make cells malignant, the team was able to identify

When it comes to vitamin D, most adults exhibit either frank deficiency, which results in clear clinical symptoms, or insufficiency, which often goes undetected. But how that insufficiency impacts physical health and the vulnerability of older adults to frailty as they age has been difficult to determine. Now a University at Buffalo study of 24-28–month-old

Nintedanib, a medication approved for the treatment of idiopathic pulmonary fibrosis, slows the decline in lung function among patients with a broad range of scarring lung diseases. The findings, published in the New England Journal of Medicine, suggest that many more people may benefit from nintedanib than are currently approved for treatment. They also suggest

There are 200 million people in the world living with age-related macular degeneration (AMD), and in approximately a fifth of these cases, the disease progresses to an advanced stage, leading to visual impairment. Advanced AMD is divided into wet and dry forms. While wet AMD can be treated with medical injections, approximately four fifths of

A team of researchers from Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College used genetic testing of cells found in cerebrospinal fluid to track certain brain tumors. In their paper published in the journal Nature, the group describes tests they conducted with cancer patients and analysis of their cerebrospinal fluid, and what they

Dana-Farber Cancer Institute scientists will present research marking significant advances against the hematologic cancer multiple myeloma at the American Society of Hematology (ASH) Annual Meeting Dec. 1-4. Their findings provide new insights into the progression of the disease from precursor conditions and suggest approaches for novel treatments. In related work, Dana-Farber investigators will also present

Scientists for the first time have used CRISPR gene editing to halt the progression of Duchenne muscular dystrophy (DMD) in a large mammal, according to a study by UT Southwestern that provides a strong indication that a lifesaving treatment may be in the pipeline. The research published in Science documents unprecedented improvement in the muscle

Two new studies have unveiled how a peculiar molecule impacts how antibody-producing cells develop and function as well as how normal melanocytes progress to melanoma malignancy. “These findings on fundamental immunology and melanoma development originate from totally different areas of research, though have intersected at the bench,” said Charles Dimitroff, Ph.D., of the Department of

In a study of patients with chronic kidney disease (CKD), persistent substance use—especially of hard illicit drugs—was linked with higher risks of CKD progression and early death. The findings appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). CKD is common in the United States, and affected patients

The Defocus Incorporated Multiple Segments (DIMS) Spectacle Lens developed by the Hong Kong Polytechnic University (PolyU) slowed down myopia progress by 60 percent in participating children; myopic progression halted completely in 21.5 percent of subjects. This lens will be launched in summer 2018, offering a non-contact, spectacle lens solution to myopic children. The lens was