Tag: Researchers

A new gene associated with disease severity in models of rheumatoid arthritis has been identified by researchers at the Icahn School of Medicine at Mount Sinai. The discovery could provide a new pathway for treatment and a way to measure the prognosis of patients diagnosed with the autoimmune condition. Through a series of experiments—on synovial

The desire for unblemished, clear skin permeates all cultures and societies, making the practice of skin lightening to minimize spots and even a skin tone quite common worldwide. Internationally, the use of creams to lighten skin is widespread and widely studied. In the U.S. however, information about use of these creams is sparse. In what

A critical link in mapping recurrent mutations of melanoma—the most serious form of skin cancer in humans—has been discovered by researchers at Washington State University School of Molecular Biosciences, in collaboration with researchers at Georgia State University. In a paper published July 6 in Nature Communications, researchers established that DNA binding by a specific set

A new study has shown that despite excellent glycemic control and low glycemic variability throughout their pregnancies, women with type 1 diabetes tended to give birth to infants who were large for gestational age. Researchers documented elevated fetal weight and abdominal circumference percentages throughout the pregnancies that were consistent with accelerated prenatal growth, as documented

Following an extensive analysis of published studies, researchers at the University of Colorado Anschutz Medical Campus have found that while suicide rates are higher at higher altitudes, they are unlikely caused by hypoxia, (low oxygen) at these elevations. The study, published this month in the journal High Altitude Medicine & Biology, says suicide victims at

With the combined efforts of three Yale laboratories, researchers conducted the first demonstration of site-specific gene editing in a fetus, correcting a mutation that causes a severe form of anemia. The technique, described in a paper published June 26 in Nature Communications, involves an intravenous injection of nanoparticles carrying a combination of donor DNA and

A genetic anomaly in certain men with prostate cancer may impact their response to common drugs used to treat the disease, according to new research at Cleveland Clinic. The findings may provide important information for identifying which patients potentially fare better when treated with an alternate therapy. In a newly published study in Journal of

The average 10-year risk of developing cardiovascular disease varies widely among India’s states, ranging from 13.2% to 19.5%, with substantial variation across socio-demographic groups according to a study published this week in PLOS Medicine by Pascal Geldsetzer and Rifat Atun of Harvard University, and colleagues. Cardiovascular disease (CVD) is the leading cause of mortality in

A team of researchers says it has linked sensitivity to an allergen in red meat to the buildup of plaque in the arteries of the heart. While high saturated fat levels in red meat have long been known to contribute to heart disease for people in general, the new finding suggests that a subgroup of

UT Southwestern researchers recently reported a basic science finding that might someday lead to better treatments for neurodegenerative diseases like a hereditary form of Lou Gehrig’s disease. In a study published in the journal Cell, Dr. Yuh Min Chook, Professor of Pharmacology and Biophysics, and Dr. Michael Rosen, Chair of Biophysics and an Investigator in

Reversing memory deficits and impairments in spatial learning is a major goal in the field of dementia research. A lack of knowledge about cellular pathways critical to the development of dementia, however, has stood in the way of significant clinical advance. But now, researchers at the Lewis Katz School of Medicine at Temple University (LKSOM)

Researchers have developed an artificial tissue in which human blood stem cells remain functional for a prolonged period of time. Scientists from the University of Basel, University Hospital Basel, and ETH Zurich have reported their findings in the scientific journal PNAS. In the bone marrow, several billion blood cells are formed each day. This constant

Human immune cells in blood can be converted directly into functional neurons in the laboratory in about three weeks with the addition of just four proteins, researchers at the Stanford University School of Medicine have found. The dramatic transformation does not require the cells to first enter a state called pluripotency but instead occurs through

Staying mentally sharp—that’s aging Americans’ highest priority, according to the National Council on Aging. While thousands of clinical trials suggest that exercising the body can protect or improve brain health as we age, few studies provide practical prescriptive guidance for how much and what kind of exercise. Now, an exhaustive systematic review of 4,600 clinical

Researchers in the University of Toronto’s Faculty of Applied Science & Engineering are combining audio and art to provide better, standardized ways of simulating and understanding medical imaging of brain aneurysms. Currently, if a patient comes into a medical clinic with an unruptured brain aneurysm, a clinician’s decision to operate or leave it depends on

Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have developed a 3-D brain organoid that could have potential applications in drug discovery and disease modeling. This is the first engineered tissue equivalent to closely resemble normal human brain anatomy, containing all six major cell types found in normal organs including, neurons and immune cells. In

Combining data from electronic health records with results from standardized depression questionnaires better predicts suicide risk in the 90 days following either mental health specialty or primary care outpatient visits, reports a team from the Mental Health Research Network, led by Kaiser Permanente research scientists. The study, “Predicting Suicide Attempts and Suicide Death Following Outpatient

Research by physician-scientists at the University of Colorado Anschutz Medical Campus offers hope for improved quality of life for people who rely on intravenous nutrition due to intestinal damage. Karim C. El Kasmi, MD, Ph.D., assistant professor of pediatrics, and Ronald Sokol, MD, professor of pediatrics, are authors of an article in the April 2018

The number of cases of progressive massive fibrosis, the most severe form of black lung disease, has been increasing dramatically among coal workers and especially younger workers in central Appalachia. These new findings represent the first-ever documentation of this spike and were presented by Kirsten Almberg, research assistant professor of environmental and occupational health sciences

Cutbacks to social programmes in Brazil could lead to more avoidable childhood hospitalisations and deaths compared to maintaining current funding. The findings come from new research, published this week in the journal PLOS Medicine and led by researchers at Imperial College London and Universidade Federal da Bahia in Brazil. Using statistical models to simulate future