Tag: system

Helping the immune system to combat cancer

Cancers sometimes escape our immune defenses because of the over-activity of molecular signaling systems, called checkpoint processes. Now we may be able to fight back using a new range of molecules, researchers in China report in the European Journal of Medicinal Chemistry. “We have been working on the discovery of anti-cancer agents for more than

How the immune system deals with the gut’s plethora of microbes

The gut is an unusually noisy place, where hundreds of species of bacteria live alongside whatever microbes happen to have hitched a ride in on your lunch. Scientists have long suspected that the gut’s immune system, in the face of so many stimuli, takes an uncharacteristically blunt approach to population control and protection from foreign

TLK protein inhibition activates the innate immune system

Tousled-like kinases (TLKs) are a potential therapeutic target for cancer treatment due to their central role in DNA repair and replication. The latest work by IRB Barcelona’s Genomic Instability and Cancer Laboratory, led by Travis H. Stracker, concludes that TLK inhibition activates the innate immune system, a very important factor in the response to cancer.

How To Take Care Of Your Digestive System

Digestion is the process of digesting food. Through a series of chemical reactions, the body breaks food down into smaller particles to aid the absorption of nutrients into the bloodstream. The complete process of digestion takes 24 to 72 hours. The exact time is dependent on several factors, including the presence of digestive issues and

The eyes are the window to the nervous system

Individuals who experience an unpleasant tingling in their hands or feet or who suffer from painful discomfort and numbness could be affected by a neuropathy—a disorder of the nervous system in which the nerve fibers become damaged and may begin to degenerate. This effect is already visible on the cornea before the first symptoms appear.

Synthetic cells capture and reveal hidden messages of the immune system

When immune cells detect harmful pathogens or cancer, they mobilise and coordinate a competent defence response. To do this effectively immune cells must communicate in a way that is tailored to the pathogenic insult. Consequently, the body’s response to various health challenges depends on successful coordination among the cells of the immune system. Key players

Making cancer stem cells visible to the immune system

Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for killer cells. This protective mechanism can be tricked with drugs. In the journal Nature, scientists from Basel, Tübingen and Heidelberg describe the new therapeutic approaches that can possibly be derived from these results. Patients with acute myeloid leukemia (AML) often

Mobilizing the lymphatic system may help combat obesity-induced metabolic syndrome

The search by scientists to find ways to combat obesity continues. Recently, investigators have been exploring whether they can engage the lymphatic system to help regulate obesity-induced inflammation of fat (adipose) tissue and restore systemic metabolic fitness. In a study appearing in he American Journal of Pathology, researchers report that augmenting lymphatic vessel formation in

Discovery of blood vessel system in bones

A network of very fine blood vessels that connects bone marrow directly with the blood supply of the periosteum that was previously overlooked has now been discovered by Dr. Anika Grüneboom, a young researcher who is now working at Universitätsklinikum Erlangen. She made this groundbreaking discovery while working on her doctoral thesis at Universität Duisburg-Essen