Cancers sometimes escape our immune defenses because of the over-activity of molecular signaling systems, called checkpoint processes. Now we may be able to fight back using a new range of molecules, researchers in China report in the European Journal of Medicinal Chemistry. “We have been working on the discovery of anti-cancer agents for more than
The gut is an unusually noisy place, where hundreds of species of bacteria live alongside whatever microbes happen to have hitched a ride in on your lunch. Scientists have long suspected that the gut’s immune system, in the face of so many stimuli, takes an uncharacteristically blunt approach to population control and protection from foreign
A Rutgers-led team has created a smart drug delivery system that reduces inflammation in damaged nervous tissues and may help treat spinal cord injuries and other neurological disorders. The system, which uses extremely thin biomaterials implanted in the body, also protects nerve fibers (axons) that connect nerve cells in injured neural tissues, according to a
Tousled-like kinases (TLKs) are a potential therapeutic target for cancer treatment due to their central role in DNA repair and replication. The latest work by IRB Barcelona’s Genomic Instability and Cancer Laboratory, led by Travis H. Stracker, concludes that TLK inhibition activates the innate immune system, a very important factor in the response to cancer.
In a recent article published in the February issue of the journal Sensors, researchers at Texas A&M University have reported a technology that might help people with gout disease monitor their symptoms better. They said their minimally invasive biosensor system may hold the key to future point-of-care therapies centered around personal management of gout, and
When it comes to memory, immune cells are known as the “bad cops” of the brain. But new research shows they could also be turned into “good cops” to power memory and learning. Inflammation can send the brain’s immune cells into damaging hyperdrive, and this has been linked to neurodegenerative diseases that affect memory, like
Digestion is the process of digesting food. Through a series of chemical reactions, the body breaks food down into smaller particles to aid the absorption of nutrients into the bloodstream. The complete process of digestion takes 24 to 72 hours. The exact time is dependent on several factors, including the presence of digestive issues and
NHS could free hospital beds and ‘save lives’ using AI which tells doctors when patients are stable enough to go home up to THREE DAYS earlier The system by a patients’ bedside collects data on their vitals It builds a picture of their condition and gives a score from zero to 20 Patients were able
Children and adolescents detained in the youth justice system experience poor health across a range of physical and mental health domains, according to new research. In the first global review, researchers from the University of Melbourne, Murdoch Children’s Research Institute (MCRI) and University of Sheffield in the UK have examined the health of detained adolescents
Researchers have cleared a major obstacle in the development of an HIV vaccine, proving in animal models that effective, yet short-lasting antibodies can be coaxed into multiplying as a fighting force against the virus. The finding, led by a team of researchers at the Duke Human Vaccine Institute (DHVI) and Boston Children’s Hospital, publishes online
Individuals who experience an unpleasant tingling in their hands or feet or who suffer from painful discomfort and numbness could be affected by a neuropathy—a disorder of the nervous system in which the nerve fibers become damaged and may begin to degenerate. This effect is already visible on the cornea before the first symptoms appear.
Dear Mayo Clinic: I am 72 and take a drug for rheumatoid arthritis that suppresses my immune system. I’m scheduled to receive a vaccine later this year. Is it safe for me to receive this vaccine? A: Appropriate and timely vaccines are important for anyone with a suppressed immune system. That’s because a suppressed immune
When immune cells detect harmful pathogens or cancer, they mobilise and coordinate a competent defence response. To do this effectively immune cells must communicate in a way that is tailored to the pathogenic insult. Consequently, the body’s response to various health challenges depends on successful coordination among the cells of the immune system. Key players
Getting up close—and a little dirty—with farm animals just might help us fend off illness, say researchers who’ve further demonstrated the benefits of early exposure to a wide variety of environmental bacteria. Scientists from The Ohio State University found that bacteria and other microbes from rural Amish babies was far more diverse—in a beneficial way—than
Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for killer cells. This protective mechanism can be tricked with drugs. In the journal Nature, scientists from Basel, Tübingen and Heidelberg describe the new therapeutic approaches that can possibly be derived from these results. Patients with acute myeloid leukemia (AML) often
A unique discovery about the nature of neutrophils—the most numerous white blood cells in the body—may lead to new models for diagnosing and tracking inflammatory diseases such as cancer and osteoarthritis. The “first responders” of the body, neutrophils are a class of leukocyte immune cell in the “innate” immune system, which deals with acute infections.
The search by scientists to find ways to combat obesity continues. Recently, investigators have been exploring whether they can engage the lymphatic system to help regulate obesity-induced inflammation of fat (adipose) tissue and restore systemic metabolic fitness. In a study appearing in he American Journal of Pathology, researchers report that augmenting lymphatic vessel formation in
Precision cancer drugs called PARP inhibitors have a previously unknown ability to boost the immune system, and could help many more patients benefit from immunotherapy, a new study reveals. Scientists found that PARP inhibitors sparked a powerful immune response when used against cancer cells with weaknesses in repairing their DNA. The study changes our understanding
A network of very fine blood vessels that connects bone marrow directly with the blood supply of the periosteum that was previously overlooked has now been discovered by Dr. Anika Grüneboom, a young researcher who is now working at Universitätsklinikum Erlangen. She made this groundbreaking discovery while working on her doctoral thesis at Universität Duisburg-Essen
In a new study published in the Journal of Experimental Medicine, scientists at the University of Notre Dame have discovered that the pathogen Mycobacterium tuberculosis (MTB) releases RNA into infected cells. This RNA stimulates the production of a compound known as interferon beta that appears to support the growth of the pathogen. As part of