Tag: transplant

Organ transplantation involves the transplantation of organs from donors as a means to treat disease or injury, but there is a shortage of organs available for donation compared to the demand for organ transplantation. Research involving the transplantation of animal organs (xenotransplantation) is ongoing, considering its potential to overcome these challenges. Heart valves and corneas

Evidence continues to mount that vaccination against COVID-19, most notably the Pfizer and Moderna vaccines, produces robust, durable protection in the vast majority of recipients. But questions remain for some at greatest risk of a severe outcome from a COVID-19 infection: Recipients of donor organs and bone marrow whose immune systems are necessarily suppressed to

Scientists at UC San Francisco, UC Berkeley and UCLA have received U.S. Food and Drug Administration approval to jointly launch an early phase, first-in-human clinical trial of a CRISPR gene correction therapy in patients with sickle cell disease using the patient's own blood-forming stem cells. The trial will combine CRISPR technology developed at Innovative Genomics

Non-circulating memory T cells, whose main function is to provide local protection against re-infection, contribute to chronic transplant rejection, University of Pittsburgh School of Medicine researchers reveal in a paper published today in Science Immunology. The scientists show that these “tissue-resident memory T cells” are harmful in situations where antigens that the cells recognize are

MONDAY, Oct. 26, 2020 — Preventive antifungal medications cut the risk for death following a lung transplant by more than half, according to a study published online Sept. 23 in the Annals of the American Thoracic Society. Kelly M. Pennington, M.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues evaluated the effect of antifungal

Certain social determinants of health predict patient-reported outcomes in potential kidney transplant recipients, according to a study that will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25. In the 955-participant study, patients’ experience of discrimination in a medical setting, greater depressive symptoms, and a lower sense of mastery (or control over

Taking a more active role in one’s own health is known to promote better outcomes, but it is especially critical for patients who are waiting for a kidney transplant. Patients with kidney failure who actively used an online patient portal to track the status of their health care improved their chances of getting a kidney

Air pollution slashes the survival chances for heart transplant patients, finds study Experts at Case Western Reserve University in Ohio tracked 22,000 people All of the patients had received a donor heart between 2004 and 2015  They compared patients’ home address against levels of PM2.5 pollution  Air pollution slashes the survival chances for people who

For patients with Type 1 diabetes who don’t respond well to insulin or have other serious medical complications caused by their disease, pancreas transplantation offers hope for a cure. But obese candidates who need a pancreas transplant often are denied the procedure because of poor outcomes, including high rates of incision infections, which are linked

“Poop transplants,” or what doctors refer to as fecal microbiota transplants (FMT), have been used in recent years as an experimental cure for Clostridium difficile, sometimes referred to as C. diff or C. difficile, which affects nearly half a million Americans each year. C. diff is a type of bacteria that can produce toxins that

Kristen Patton was settling in to feed her newborn on Christmas Eve as her three older children went to bed. It was the holiday evening she had envisioned—relaxed family time the day after coming home from the hospital following the birth of her daughter, Hattie. Suddenly, unbelievable pain shot through Kristen’s left jaw. It moved

Woman, 68, who received a lung transplant develops her donor’s peanut allergy in ‘very rare’ phenomenon The unnamed patient, from San Diego, had never had a reaction to nuts before When doctors heard a sandwich triggered her symptoms they were suspicious Nut allergies are only believed to have been passed on four or five times

In an American Journal of Transplantation study, lung cancer risk was increased after lung transplantation, especially in the native (non-transplanted) lung of single lung transplant recipients. This was a large registry-linkage study that utilized matched transplant and cancer registry data from 17 US states/regions, including approximately 50 percent of US transplant recipients from 1987-2012. Researchers

‘Artificial’ kidney that could mean thousands won’t need dialysis or a transplant Implant that mimics functions of the human kidney could begin trials this year  It could be a life-saving option for patients with chronic kidney disease If successful it would save patients from dialysis or needing a transplant A coffee cup-sized implant that mimics the

Among organ transplant patients, those receiving new lungs face a higher rate of organ failure and death compared with people undergoing heart, kidney and liver transplants. One of the culprits is inflammation that damages the newly transplanted lung. Now, researchers at Washington University School of Medicine in St. Louis and Northwestern University Feinberg School of

Kendra Plumley didn’t spend her childhood running around with other kids on her street, having friends over for sleepovers, or spending lazy summer days by the pool. Instead, she spent most of her time indoors. It wasn’t a choice. She had to protect her new heart. Today, the 29-year-old from Midlothian, Texas, is making up

An international research team has today reported the first results of a study investigating the natural history of progressive familial intrahepatic cholestasis (PFIC)—a rare genetic liver disease that predominantly affects children. Most alarmingly, the team reported that, by the age of 10 years, approximately half of the children with two different forms of PFIC had

The results of an international clinical trial for a new system of diagnosing heart transplant rejection and injury will be presented publicly for the first time at the International Society for Heart & Lung Transplantation (ISHLT) annual meeting, which will take place on April 11 and 12 in Nice, France. Led by Dr. Phil Halloran