Tag: target

New pharmaceutical target reverses osteoporosis in mice

Biomedical engineers at Duke University have discovered a pharmaceutical target that, when activated, can reverse bone degradation caused by osteoporosis in mouse models of the disease. “The most widely used drugs currently approved by the FDA to treat osteoporosis can prevent further bone loss, but they don’t help rebuild the bone,” said Shyni Varghese, professor

Target Is Selling Cheap Sangria Just In Time for Summer

Target is our go-to spot for all things summer, whether we’re looking for a new bathing suit, patio furniture, or sunscreen. But now, they’re even more essential to our summer shopping routine, because this year, Target will be selling a $5 bottle of sangria, part of their California Roots wine collection. California Roots is basically

Researchers discover therapeutic target of melanoma

Researchers have identified a biomarker and a possible new therapy for melanoma. Microphthalmia-associated transcription factor (MITF) is a protein that plays a pivotal role in the maintenance of the melanocyte (cells that make melanin) lineage, differentiation of normal and malignant melanocytes and the survival of melanoma cells. “We have now detected the first useful chemical

Super-enhancers: novel target for pancreatic ductal adenocarcinoma

Differential H3K27AC marks were identified at enhancer regions of genes including c-MYC, MED1, OCT-4, NANOG, and SOX2 that can act as super-enhancers (SE), cluster of genes in non-cancerous, cancerous and metastatic PDAC cell lines. GZ17-6.02 affects acetylation of the genes, reduces transcription of major transcription factors, sonic hedgehog pathway proteins, and stem cell markers. Dr.

Potential therapeutic target for lung fibrosis identified

In an article published online by Frontiers in Endocrinology, researchers at the Medical University of South Carolina (MUSC) report that they have identified a potential therapeutic target for lung fibrosis or scarring. They showed in a preclinical model that the protein promotes fibrosis by turning on profibrotic genes and increasing levels of profibrotic factors, including

Effective new target for mood-boosting brain stimulation found

Researchers have found an effective target in the brain for electrical stimulation to improve mood in people suffering from depression. As reported in the journal Current Biology on November 29, stimulation of a brain region called the lateral orbitofrontal cortex (OFC) reliably produced acute improvement in mood in patients who suffered from depression at the

New way to target advanced breast cancers

A cytokine signature found in certain kinds of breast cancer cells can not only serve as a diagnostic tool for HER2-negative cancers but also offer an effective treatment target. A research team led by Karolina Palucka, M.D., Ph.D., a professor at The Jackson Laboratory (JAX), has collaborated with researchers at The Baylor Institute for Immunology

S.W. Basics Expands Lineup, Gains Whole Foods

Flower water hydrosols are gaining traction in the natural skin-care market. But, according to Adina Grigore, founder of S.W. Basics, most of the products being marketed as hydrosols are waters that are merely scented with additives. A core principle of S.W. Basics, which Grigore launched in 2011, is to make products with five ingredients or

A new molecular target identified in depression

The discovery of a new mechanism involved in depression – and a way to target it with a drug as effective as classical antidepressants—provides new understanding of this illness and could pave the way for treatments with fewer side effects. In a study published in Nature Medicine, a team of scientists at McGill University and

A potential new therapeutic target for Ewing sarcoma

The sarcoma research group of the Bellvitge Biomedical Research Institute (IDIBELL), led by Dr. Òscar Martínez-Tirado, has identified a potential new therapeutic target for Ewing sarcoma, the second most frequent bone cancer in children and adolescents, and a tumor known for its aggressiveness and tendency to metastasize. The research is published in the International Journal

Taming an unruly target in diabetes

Focusing on a simple hormone in us all, a Yale researcher has found specific forms of it that poke toxic holes in cells—a discovery that he is leveraging into a treatment for patients with diabetes. The research, published April 3 in Nature Communications, is also central to the recent awarding of two grants totaling $600,000