Tag: breakthrough

With global rates of male infertility continuing to rise, a new study in spermatogonial stem cell research led by researchers at the University of Georgia provides hope for future clinical therapies. The study, which was published recently in Fertility and Sterility Science, is the first to show that functional sperm cells can be made in

While rare, botulism can cause paralysis and is potentially fatal. It is caused by nerve-damaging toxins produced by Clostridium botulinum—the most potent toxins known. These toxins are often found in contaminated food (home canning being a major culprit). Infants can also develop botulism from ingesting C. botulinum spores in honey, soil, or dust; the bacterium

Two years after discovering a way to neutralize a rogue protein linked to Alzheimer’s disease, University of Alberta Distinguished University Professor and neurologist Jack Jhamandas has found a new piece of the Alzheimer’s puzzle, bringing him closer to a treatment for the disease. In a study published in Scientific Reports, Jhamandas and his team found

A molecular process involved in the action of anti-leukemia drugs has been discovered at Université de Montréal’s Institute for Research in Immunology and Cancer (IRIC). While calling into question a central tenet of oncology, this discovery, published today in the journal Cancer Cell, also holds promise for the development of effective treatments in the near

Infectious proteins called prions cause a group of related, fatal and incurable neurodegenerative disorders, including bovine spongiform encephalopathy or Mad Cow disease and Creutzfeldt-Jakob disease, both of which affect humans. Chronic wasting disease or CWD, also caused by prions, has reached the point of a global epidemic among deer, elk and members of the deer

New research published in the Journal of Physiology presents a breakthrough in the treatment of Restless Legs Syndrome (RLS). RLS is a common condition of the nervous system that causes an overwhelming irresistible urge to move the legs. Patients complain of unpleasant symptoms such as tingling, burning and painful cramping sensations in the leg. More

Scientists have discovered a drug combination that could halt the progression of fibrosis—a condition believed to be responsible for almost half of all deaths—according to a study published in the journal European Urology. Researchers from Anglia Ruskin University, University College London and KU Leuven have spent seven years working on finding the right drug combination

THURSDAY, Oct. 18, 2018 — In what researchers are calling a “breakthrough,” two preliminary trials have found that either of two triple-drug regimens could potentially benefit 90 percent of people with cystic fibrosis. The trials were short-term, finding that the drug combinations improved adult patients’ lung function over four weeks. But experts said they were

A new study by KAIST researchers identified where the mutation causing glioblastoma starts. According to the study, neural stem cells away from the tumor mass are the cells of origin that contain mutation drivers for glioblastoma, one of the most aggressive brain tumor. This breakthrough research, reported in Nature on August 1, gives insights for

TUESDAY, July 17, 2018 — Pivotal trials supporting U.S. Food and Drug Administration approvals granted Breakthrough Therapy designation often lack randomization, double-blinding, and control groups, according to a research letter published in the July 17 issue of the Journal of the American Medical Association. Jeremy Puthumana, from the Yale University School of Medicine in New

A first-ever tissue implant to safely treat a common jaw defect, known as temporomandibular joint dysfunction, has been successfully tested by UCI-led researchers in a large animal model, according to new findings. “We were able to show that we could achieve exceptional healing of the TMJ area after eight weeks of treatment,” said UCI distinguished

Prostate cancer breakthrough: New DNA test identifies men who are SIX TIMES more likely to develop the disease Researchers identified 63 new genetic mutations linked to the condition  Combined with over 100 variants known to cause the cancer to make the test One in 100 men carry sufficient numbers of genetic variations to put them

Clinical trial results presented today at a prestigious cancer meeting in Chicago show substantial increased survival rates for pancreatic cancer patients who received a four-drug chemotherapy combination known as mFOLFIRINOX after surgery. Pancreatic cancer is typically very aggressive, with only approximately eight per cent of people surviving beyond five years after diagnosis, even after surgery