Tag: Drug

The human liver is a vital organ involved in multiple functions. Because susceptibility to liver diseases is highly variable among patients, researchers from Tokyo Medical and Dental University (TMDU) and Cincinnati Children’s Hospital Medical Center (CCHMC) have engineered a model liver system that can be personalized for disease modeling and drug discovery. In a study

The pharmaceutical company, Cortexyme, Inc. has outlined a trial of potential Alzheimer’s drug that targets toxic substances released by P. gingivalis, a bacteria linked to gum disease. In a poster presented at the Alzheimer’s Association International Conference today (Wednesday, July 17), researchers provided an overview of the development of the drug, known as COR388, and

Stopping the spread of Shiga toxins released by E. coli bacteria, which are potentially fatal if they reach the kidneys, has been a focus of researchers for years. No treatments for STEC currently exist, and antibiotic therapy cannot be used because it increases release of Shiga toxins from the bacteria. Approved antidotes are also not

The times are changing, and so are drug and alcohol use trends among American youth. These shifts in illicit substance use will compel primary care physicians to monitor new products and how they are used, two University at Buffalo researchers write in this month’s issue of American Family Physician. “It is important to improve our

A new drug that inhibits neonatal seizures in rodent models could open up new avenues for the treatment of epilepsy in human newborns. Researchers have identified that gluconate—a small organic compound found in fruit and honey—acts as an anticonvulsant, inhibiting seizures by targeting the activity of channels that control the flow of chloride ions in

In experiments with pregnant mice infected with the Zika virus, Johns Hopkins Medicine researchers report they have successfully used a long-standing immunosuppressive drug to diminish the rate of fetal deaths and birth defects in the mice’s offspring. The U.S. Food and Drug Administration-approved medicine, anakinra, once commonly used to treat rheumatoid arthritis and other autoimmune

People whose high cholesterol is resistant to treatment with statin drugs may soon have a new treatment option. This new class of drugs helps block synthesis of artery-clogging cholesterol, researchers explained. The drugs target an enzyme called ATP citrate lyase (ACL), part of the production pathway for “bad” LDL cholesterol in the body. In the

Gonorrhoea is the second most commonly notified sexually transmitted infection across the EU/EEA countries with almost 500 000 reported cases between 2007 and 2016. The infection is treatable but Neisseria gonorrhoeae keep showing high levels of azithromycin resistance according to latest results of the European Gonococcal Antimicrobial Surveillance Programme. This antibiotic agent is part of

Schoolboy, 8, is ‘living with a death sentence’ because the NHS won’t fork out for £100,000-per-year cystic fibrosis ‘wonder drug’ George Monckton could be saved from lung deterioration by Orkambi  It could extend the lives of patients who often die before reaching middle age Drug is unavailable on NHS because of a deadlock in price

A new drug shows potential to halt cancer cells’ growth by stunting the cells’ biological clock. The findings from scientists at the USC Michelson Center for Convergent Bioscience and Nagoya University’s Institute of Transformative BioMolecules (ITbM) advance a burgeoning area of research: turning the body’s circadian rhythms against cancer. Their study, conducted on human kidney

Crippling anxiety suffered by obese people could be halted by a drug cocktail that ‘wipes out dangerous ZOMBIE cells thought to hamper their mental health’ ‘Zombie cells’ have been shown to accumulate in the brains of obese people Also known as senescent cells, they are alive but do not function properly  In dangerously overweight mice,

A meta-analysis of randomized controlled trials found that catheter ablation was superior to conventional drug therapy alone for patients with atrial fibrillation and heart failure. Findings are published in Annals of Internal Medicine. Atrial fibrillation is associated with thromboembolic stroke, systemic embolism, and decompensated heart failure. Catheter ablation is an established therapeutic strategy for atrial

An experimental drug known as A03, which was previously developed to treat depression, increases the levels of the enzyme Sirtuin1, or SirT1, and improves memory in mice. The mice were genetically modified to have a protein called ApoE4, the most common genetic risk factor for Alzheimer’s disease in humans that has been linked to some

A novel way in which the inflammatory response to pain is regulated has been described in the open-access journal eLife. The results add to our understanding of the mechanisms that cause increased sensitivity to pain in response to injury and inflammation, and could pave the way for more effective therapies. Inflammatory hyperalgesia, the hypersensitivity to

THURSDAY, Nov. 1, 2018 — The first cannabis-based medication approved by the U.S. Food and Drug Administration is now available by prescription nationwide. Epidiolex is a twice-daily oral solution approved for use in patients age 2 years and older with two types of epileptic syndromes, Dravet syndrome and Lennox-Gastaut syndrome, CNN reported. The FDA approved

For the first time in nearly two decades, the U.S. Food and Drug Administration (FDA) has approved a new flu drug for the treatment of influenza. The new medication, called Xofluza (baloxavir marboxil), joins Tamiflu and other antiviral medicines as available options for people who get sick—and want to feel better faster—this flu season. Xofluza

Benylin’s range of cough medicines all contain ‘IDENTICAL’ ingredients – despite being marketed differently The 46-year-old, AKA the MoneySavingExpert, took to Twitter on Thursday Warned customers not to believe that the £4.99 tablets offer ‘something extra’ Previously, Lewis urged people not to pay inflated price of branded medicines Benylin’s range of cough medicines have been

Viagra could damage your eyes! Erection drug bought online leaves 31-year-old man with red-tinted vision (and doctors warn the damage is irreversible) The unnamed New York man took ‘much more’ than the recommended dose Doctors found his eyes were left physically damaged and couldn’t be healed The effects began shortly after the man took a

A tumor-specific vaccine combined with an immune checkpoint inhibitor shrank tumors in one third of patients with incurable cancer related to the human papilloma virus (HPV) in a phase II clinical trial led by investigators at The University of Texas MD Anderson Cancer Center and reported in JAMA Oncology. “That encouraging response rate is about

If you plan to try and quit junk food, expect to suffer similar withdrawal-type symptoms—at least during the initial week—like addicts experience when they attempt to quit using drugs. A new study by University of Michigan is believed to be the first of its kind to evaluate withdrawal symptoms people incur when they stop devouring