Tag: lead

Preclinical data on lead coronaviruses antibody

Adagio Therapeutics today published in vitro and in vivo data in Science on its lead antibody candidate, ADG2, which demonstrated similar or higher potency against SARS-CoV-2 compared to other monoclonal antibodies (mAbs) in clinical development and strong binding to all known SARS-CoV-2 variants. Uniquely, ADG2 also showed broad and potent neutralization against a range of

3-D miniature livers lead the way to patient-specific drug discovery

The human liver is a vital organ involved in multiple functions. Because susceptibility to liver diseases is highly variable among patients, researchers from Tokyo Medical and Dental University (TMDU) and Cincinnati Children’s Hospital Medical Center (CCHMC) have engineered a model liver system that can be personalized for disease modeling and drug discovery. In a study

Injury to a parent can lead to sleep issues in children and teens

Research has shown that getting a good night’s sleep plays an important role in children’s growth and development, both physically and emotionally. When children face an unsettling experience, such as the injury of a parent, it can alter their sleep habits, according to new research being presented at the 2018 American Academy of Pediatrics National

Two quality improvement programs lead to fewer postoperative complications

Two presurgery checklists from the American College of Surgeons (ACS) Strong for Surgery (S4S) program that incorporate best practices for engaging patients in preparing for their upcoming operations significantly improved lifestyle factors that pose an increased risk for postoperative complications or help support healing and postoperative recovery. At CHRISTUS St. Michael Health System, Texarkana, Tex.,

Early life exposure to famine can lead to depression

New research from the University of Georgia reveals that exposure to famine during specific moments in early life is associated with depression later in life. “Nutrition deprivation and stress are important risk factors for depression particularly during periods in early life,” said lead author Changwei Li, assistant professor of epidemiology and biostatistics at UGA’s College

Thyroid dysfunction may lead to diabetes during pregnancy

Women with thyroid dysfunction in the first half of pregnancy face an increased risk for gestational diabetes, a form of diabetes that is typically diagnosed during the second trimester, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism. Thyroid dysfunction is common among pregnant women and has been

Insomnia causes the brain to ‘eat itself’, study finds 

Insomnia causes the brain to ‘eat itself’ and may lead to Alzheimer’s, study finds Sleep is important to clear away brain cell ‘wear and tear’, research suggests Yet, insomnia causes this to go into overdrive and remove healthy brain cells Previous research suggests the removal of such cells is linked to Alzheimer’s The study was