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Researchers determine atomic structure of molecular complex associated with birth defects

In a study published today in Science, UT Southwestern and Rockefeller University researchers used advanced microscopes to determine at atomic resolution the structure of a molecular complex implicated in birth defects and several cancers. The Hedgehog signaling pathway, which transmits information to embryonic cells, is crucial to human health. Insufficient signaling during development leads to

Doctors’ intuition linked to number of imaging tests ordered

(HealthDay)—Doctors’ intuition plays a role in determining how many imaging tests are ordered for a patient, according to research presented at the 40th International Conference of the IEEE Engineering in Medicine and Biology Society, held from July 17 to 21 in Honolulu. Mohammad M. Ghassemi, Ph.D., from the Massachusetts Institute of Technology in Boston, and

Side effects of antibiotics

According to the Centers for Disease Control and Prevention (CDC), adverse reactions to antibiotics are responsible for 1 in 5 medication-related emergency room visits. People should always talk with a doctor if antibiotics cause bothersome symptoms. Call 911 and immediately stop taking antibiotics if side effects are severe or interfere with breathing. Common side effects

Glycans at the ‘I’ of the storm in humoral immunity and melanoma progression

Two new studies have unveiled how a peculiar molecule impacts how antibody-producing cells develop and function as well as how normal melanocytes progress to melanoma malignancy. “These findings on fundamental immunology and melanoma development originate from totally different areas of research, though have intersected at the bench,” said Charles Dimitroff, Ph.D., of the Department of

UN warns of a possible new cholera epidemic in Yemen

The United Nations is warning of a possible “third wave” of the cholera epidemic in Yemen, which is already “the largest outbreak on record.” U.N. spokesman Stephane Dujarric said Wednesday there have been more than 1.1 million suspected cases of cholera since April 2017, and the number is increasing. He said over 2,300 deaths have

AMP addresses clinical relevance of DNA variants in chronic myeloid neoplasms

The Association for Molecular Pathology (AMP), the premier global molecular diagnostics professional society, today published consensus, evidence-based recommendations to aid clinical laboratory professionals with the management of most Chronic Myeloid Neoplasms (CMNs) and development of high-throughput pan-myeloid sequencing testing panels. The report, “Clinical Significance of DNA Variants in Chronic Myeloid Neoplasms (CMNs): A Report of

Experts Offer Tips for Provider Appeal of Denied Medical Claims

MONDAY, Aug.20, 2018 — Knowing payer policies and regulatory requirements is critical to appealing denials, according to an article published in Medical Economics. Michael Strong, a bill review technical specialist at SFM Mutual Insurance Co. in Bloomington, Minn., and Tammy Tipton, owner of Appeal Solutions Inc. in Oklahoma City, suggest several tips to ease the

NIH begins clinical trial of live, attenuated Zika vaccine

Vaccinations have begun in a first-in-human trial of an experimental live, attenuated Zika virus vaccine developed by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The trial will enroll a total of 28 healthy, non-pregnant adults ages 18 to 50 at the Johns Hopkins Bloomberg

Marijuana may improve quality of life in head and neck cancer

(HealthDay)—For patients with newly diagnosed head and neck cancer (HNC), quality of life may improve with marijuana use, according to a study published online Aug. 2 in JAMA Otolaryngology-Head & Neck Surgery. Han Zhang, M.D., from McMaster University in Hamilton, Canada, and colleagues conducted a prospective cohort study involving patients enrolled at the time of

New information to understand regulation of muscle function in muscular dystrophy patients

Scientists from the University of Jyväskylä, Finland, and from University of Cambridge, United Kingdom, have found new functions and structural details of muscle attachment structures. The research is important for the basic understanding of regulation of muscle function, for instance, in muscular dystrophy patients and for muscle adaptation in physical activity and sports. In multicellular

Gene Test Predicts Risk of 5 Common Diseases

TUESDAY, Aug. 14, 2018 — A new type of genetic analysis could identify millions of Americans at high risk for five serious and common diseases, researchers report. The diseases include coronary artery disease, the heart rhythm disorder atrial fibrillation, type 2 diabetes, inflammatory bowel disease and breast cancer. Researchers tested and validated the genetic risk

Home-delivered meals keep heart failure patients out of hospital

The delivery of personalized, low-sodium meals to the homes of heart failure patients just out of the hospital has the potential to help them avoid rehospitalization in the days ahead, a new study shows. Poor nutrition and excessive sodium consumption are common among patients with heart failure and are thought to contribute to their hospitalizations.

The inequalities of prenatal stress

Exposure to an acute stress in utero can have long-term consequences extending into childhood – but only among children in poor households, according to a new Stanford study that looked at the long-term impact of acute, parental stress. Because stress is often confounded with other factors, the study used a natural disaster – a strong