Tag: protein

TLK protein inhibition activates the innate immune system

Tousled-like kinases (TLKs) are a potential therapeutic target for cancer treatment due to their central role in DNA repair and replication. The latest work by IRB Barcelona’s Genomic Instability and Cancer Laboratory, led by Travis H. Stracker, concludes that TLK inhibition activates the innate immune system, a very important factor in the response to cancer.

Protein shredder regulates fat metabolism in the brain

A protein shredder that occurs in cell membranes of brain cells apparently also indirectly regulates the fat metabolism. This is shown by a recent study by the University of Bonn. The shredder, known as gamma-secretase, is considered a possible target for drugs against cancer and Alzheimer’s disease. However, the results suggest that such agents may

Missing protein in brain causes behaviors mirroring autism

Scientists at Rutgers University-Newark have discovered that when a key protein needed to generate new brain cells during prenatal and early childhood development is missing, part of the brain goes haywire—causing an imbalance in its circuitry that can lead to long-term cognitive and movement behaviors characteristic of autism spectrum disorder. “During brain development, there is

4 Easy, Delicious Ways to Eat More Protein

You know protein is important for a healthful diet. It builds and maintains muscle. It helps you fill up faster and stay full longer. It is delicious. Yet despite the fact that 55 percent of American households report that high protein is an important factor when buying groceries, they’re confused about what actually constitutes a

Solving long-sought protein structure opens new avenues for treating disease

Scientists at Sanford Burnham Prebys have identified the long-sought structure of an essential blood protein: vitronectin. Knowing the protein’s structure—an advance that enables rational drug design—could lead to medicines that kill multi-drug-resistant bacteria, halt cancer metastasis, treat age-related macular degeneration (AMD) and more. The study was published in Science Advances.  “For decades, scientists have speculated

Genetically manipulating protein level in colon cancer cells can improve chemotherapy

Colorectal cancer outcomes may improve by genetically altering an immune-regulatory protein in cancer cells, making the cells more vulnerable to chemotherapy. That’s according to new Mayo Clinic research. The findings, published this month in Oncogene, indicate that increasing the expression of the PD-L1 protein in colorectal cancer cells can improve the effectiveness of chemotherapy. “These

Protein offers protection against nerve degeneration in ALS model

Increasing the levels of the anti-aging protein hormone Klotho improves the neurological deficits and prolongs life span in an experimental model with Amyotrophic Lateral Sclerosis (ALS). In addition, brain immune cells called microglia play an important role in protecting the brain against inflammation and, likely, motor neuron loss in this model. ALS or Lou Gehrig’s