Tag: protein

Researchers at the California Institute of Technology in Pasadena have developed a software tool called "Variant Database" that has detected an emerging lineage of severe acute respiratory coronavirus 2 (SARS-CoV-2) isolates in New York. The novel SARS-CoV-2 virus is the agent responsible for the coronavirus disease 2019 (COVID-19) pandemic that continues to sweep the globe

The etiological agent of the coronavirus disease 2019 (COVID-19) – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – was first identified in Wuhan, China, in December 2019. Since then, the virus has infected more than 107 million people worldwide and caused over 2.4 million deaths. Due to its high transmissibility, it has been difficult to

Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma. The reduction is caused by changes in the cancer cells' metabolism. These changes can be used as markers to discriminate whether a patient would respond to treatment

Researchers in the United States who tracked the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an immunocompromised patient found that convalescent plasma therapy was associated with the emergence of viral variants that were less susceptible to neutralizing antibodies. The SARS-CoV-2 virus is the agent responsible for the coronavirus 2019 (COVID-19) pandemic that

With new variants emerging, often showing increased transmissibility and virulence, governments and health organizations do not appear to be within striking distance of effectively containing the ongoing coronavirus disease 2019 (COVID-19) pandemic. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), this condition presents with a wide spectrum of severity, ranging from asymptomatic infection

Amyloid plaques are aggregates of misfolded proteins that form in the spaces between nerve cells. These abnormally configured proteins are thought to play a central role in Alzheimer's disease. The amyloid plaques first develop in the areas of the brain concerned with memory and other cognitive functions. The amyloid hypothesis Amyloid plaques form when pieces

Breastfeeding is still common and continues for a prolonged period in developing countries, whereas its rate has declined steeply in developed nations following the introduction of formula for babies. Women who immigrate to these regions tend to take on the lactational characteristics of their host countries around the beginning of the 19th century. Health Benefits

Skip to: How allergies usually work? Types of Pollen Allergies Diagnosis of Pollen Allergies How to Treat Pollen Allergies? Pollen grains are released by trees, flowers and other plans with to fertilize other plants of the same species. An allergy to pollen is one of the most allergic reactions is the USA. Studies show that

How do you multiplex an immunoassay? There are two main ways of multiplexing an immunoassay; by separating the individual assays into different spaces (spatial separation) or by immobilizing antibodies onto different beads based on what they target. Jarun Ontakrai | Shutterstock Spatial separation is typically achieved by placing antibodies in different parts of a shared

Inflammation of the pancreas is referred to as pancreatitis. The pancreas is a flat tadpole-shaped gland located at the back of the stomach in the upper abdomen; it releases certain enzymes and hormones which help in digestion and aids in regulating sugar metabolism in the body. Pancreatitis may manifest in both severe and acute forms.

Skip to: Stroke and its Pathways Biomarkers and Risk Scores What are the Benefits of Using Biomarkers? Stroke, a complication of atrial fibrillation, can be fatal. Identification of biomarkers to predict stroke may help treat those at highest risk. Given the association between atrial fibrillation and other poor disease outcomes, biomarker identification has applications for

For most proteins that have had their structure determined, this has been done using protein crystallography. When the macromolecular structure of a protein is determined in this way, it is firstly crystalized by supersaturation, which causes each protein molecule to stack with its neighbors in a repeating pattern. The sample then undergoes x-ray crystallography, which

The isolation of DNA was successfully carried out in 1869. However, its sequencing had to wait until the Human Genome Project was completed in 2003, more than a hundred years later. vitstudio | Shutterstock Modern genomics dates back to the 1970s, but its foundation was laid at least twenty years before this, with the creation

SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells. Professor Johanna Ivaska's research group at Turku Bioscience observed that SORLA functionally contributes to the most reported therapy-resistant mechanism by which the cell-surface receptor HER3 counteracts HER2 targeting therapy in HER2-positive cancers. Removing

Researchers at The University of Texas MD Anderson Cancer Center have discovered that a protein called NF-kappa B-inducing kinase (NIK) is essential for the shift in metabolic activity that occurs with T cell activation, making it a critical factor in regulating the anti-tumor immune response. The preclinical research, published today in Nature Immunology, suggests that

Researchers from the Departments of Cell Biology and Medical Physiology at the University of Seville have identified that a high expression of the human protein VRK1 is associated with tumor aggressiveness and low survival among neuroblastoma patients. Aggressive neuroblastoma is one of the most common solid childhood cancers and causes disproportionately high mortality in affected

If you want to build muscle and achieve your fitness goals, downing the right fuel after a workout is nearly as important as exercise itself, say experts within the nutrition field. “Nailing your post-workout nutrition promotes quicker recovery, reduces muscle soreness, builds muscle, improves immune system functioning, and replenishes glycogen — all key building blocks

A decade-long study has identified the factor produced by a common species of skin bacteria that triggers eczema, in a breakthrough of our understanding of the condition. The discovery of a missing link by an international team led by University of Manchester scientists could lead to new treatments for the sometimes debilitating skin condition which

New research published in Diabetologia (the journal of the European Association for the Study of Diabetes) shows that antibody responses to SARS-CoV-2 are similar in COVID-19 patients with and without diabetes, and thus are unlikely to be responsible for the higher death rates in patients with diabetes. Furthermore, they found that a particular antibody response

Tousled-like kinases (TLKs) are a potential therapeutic target for cancer treatment due to their central role in DNA repair and replication. The latest work by IRB Barcelona’s Genomic Instability and Cancer Laboratory, led by Travis H. Stracker, concludes that TLK inhibition activates the innate immune system, a very important factor in the response to cancer.