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High virus count in the lungs drives COVID-19 deaths

A buildup of coronavirus in the lungs is likely behind the steep mortality rates seen in the pandemic, a new study finds. The results contrast with previous suspicions that simultaneous infections, such as bacterial pneumonia or overreaction of the body’s immune defense system, played major roles in heightened risk of death, the investigators say. Led

Macrophages play key role in lung damage during COVID-19

A KAIST immunology research team found that a specific subtype of macrophages that originated from blood monocytes plays a key role in the hyper-inflammatory response in SARS-CoV-2 infected lungs, by performing single-cell RNA sequencing of bronchoalveolar lavage fluid cells. This study provides new insights for understanding dynamic changes in immune responses to COVID-19. In the

Primary care plays key role in vaccinating older individuals

(HealthDay)—Primary care physicians have been the largest provider of vaccinations for older individuals, according to a study published online in the July 1 issue of the Annals of Family Medicine. Elizabeth Wilkinson, from the Robert Graham Center for Policy Studies in Family Medicine and Primary Care in Washington, D.C., and colleagues used 2017 Medicare Part

US judge rules in favor of university’s vaccine mandate

A US federal judge on Monday upheld a university’s decision to require its students and employees to get vaccinated against COVID-19, the first ruling on an increasingly divisive issue ahead of the new school year. The decision by Judge Damon Leichty of the South Bend court, around 75 miles (120 kilometers) east of Chicago, can

MRI can cut overdiagnoses in prostate-cancer screening by half

Most countries have not introduced nationwide prostate-cancer screening, as current methods result in overdiagnoses and excessive and unnecessary biopsies. A new study by researchers at Karolinska Institutet in Sweden, which is published in the New England Journal of Medicine, indicates that screening by magnetic resonance imaging (MRI) and targeted biopsies could potentially cut overdiagnoses by

Soft tissue regeneration in a cell-free scaffold microenvironment

In a new report now published on Scientific Reports, Irini Gerges and a team of scientists in Italy and the U.S. studied the importance of biomechanical and biochemical cues to create culture conditions suited for three-dimensional (3D) regenerative microenvironments and soft tissue formation. The team observed changes in adipogenesis relative to the 3D mechanical properties

Covid spreading in Africa at record pace, says WHO

The Delta variant of coronavirus is driving the pandemic forward in Africa at record speeds, the World Health Organization (WHO) warned on Thursday. Infection numbers have increased in Africa for six weeks running, rising by a quarter week-on-week to almost 202,000 in the week that ended Sunday, it said. The continent’s weekly record currently stands

Third Australian city in lockdown over virus fears

Residents of Perth in Australia’s west woke to a four-day snap lockdown Tuesday, making it the country’s third major city under stay-at-home orders as the contagious Delta variant spreads. Just three positive cases have been diagnosed in Perth since the outbreak was detected but local health officials have long taken a highly cautious approach to

COVID trajectory in Africa very, very concerning: WHO

The World Health Organization voiced alarm Friday at surging COVID-19 cases across Africa, with the spread of new more contagious variants even as vaccination rates remain dangerously low. “It’s a trajectory that is very, very concerning,” WHO’s emergencies chief Michael Ryan told reporters from the organisation’s headquarters in Geneva. According to WHO data, the number

Disparities in COVID-19 rates among adults with kidney failure in New York City

In an analysis of patients on hemodialysis in New York City, there were substantial racial/ethnic disparities in COVID-19 rates that were not explained by neighborhood social vulnerability. The findings appear in an upcoming issue of JASN. The COVID-19 pandemic has disproportionately affected socially disadvantaged groups, including Black and Hispanic individuals, those with limited English proficiency,