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A deep-dive into the impact of arthritis drugs on gene expression

A new computational framework has revealed key differences between four rheumatoid arthritis medications and their impact on biological pathways in mice. Niki Karagianni of Biomedcode Hellas SA, Greece, and colleagues present their new approach and findings in PLOS Computational Biology. People with rheumatoid arthritis often receive medications that target and inhibit Tumor-Necrosis Factor (TNF), a

Opioids: Leading cause of pregnancy-related death in new Utah moms

As the opioid epidemic rages on, one vulnerable group—new moms—have often been overlooked. A new study at the University of Utah Health found that drug-induced death is the most common cause of pregnancy-associated death in Utah. Postpartum women who have previously or currently struggle with substance abuse are at greater risk of overdosing. The research

A comprehensive map of how Alzheimer’s affects the brain

MIT researchers have performed the first comprehensive analysis of the genes that are expressed in individual brain cells of patients with Alzheimer’s disease. The results allowed the team to identify distinctive cellular pathways that are affected in neurons and other types of brain cells. This analysis could offer many potential new drug targets for Alzheimer’s,

Keeping fit is more than physical—it’s a state of mind

According to a new study differences in what motivates individuals and how they self-regulate behavior influence how they keep fit. The study appearing in the journal Heliyon, published by Elsevier, associates personal characteristics with whether people are likely to prefer solo or group exercise activities, CrossFit training, resistance training, or team sports, how frequently they

The old ways of reintegrating young veterans need to be abandoned

The reintegration of former child soldiers is a key mandate of humanitarian organisations across the globe. In most African war-torn countries, child soldiers’ reintegration strategies tend to revolve around the vocational training and mainstream education. Such operations are characterised by uneven or limited success. Accordingly, unlucky former child soldiers find themselves stuck in a cycle

'New wave of change' coming to healthcare

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