Tag: Alzheimer’s

Girl with ‘Alzheimer’s’ defies death sentence to start pre-school

Girl, four, with ‘childhood Alzheimer’s’ defies her death sentence to start pre-school and ballet classes after taking a trial drug Marian McGlockin diagnosed with Niemann-Pick disease type C (NPC) aged one  Cruel disease causes organ damage, muscle stiffness, seizures and dementia  Child, from California, has taken part in clinical trial of drug known as VTS 270 Youngster now

Pioneering head device ‘can REVERSE Alzheimer’s memory loss’

Alzheimer’s breakthrough as pioneering head device ‘can REVERSE memory loss’ using electromagnetic waves to break up clumps of toxic proteins, experts claim Transcranial electromagnetic treatment breaks down clumps of toxic proteins This can free up previously-blocked nerve cells and help them function normally  The quest for Alzheimer’s treatments has for decades hit massive roadblocks  A

Alzheimer’s drug trial targets by-product of gum disease

The pharmaceutical company, Cortexyme, Inc. has outlined a trial of potential Alzheimer’s drug that targets toxic substances released by P. gingivalis, a bacteria linked to gum disease. In a poster presented at the Alzheimer’s Association International Conference today (Wednesday, July 17), researchers provided an overview of the development of the drug, known as COR388, and

Alzheimer’s disease: Sex affects tau accumulation in the brain

The strongest genetic risk factor for Alzheimer’s disease is the apolipoprotein E type 4 allele (ApoE ε4). Research presented by Manish Paranjpe at the 2019 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) used positron emission tomography (PET) to show that women who are ApoE ε4 carriers and already experiencing mild

Epilepsy drugs linked to increased risk of suicidal behavior, particularly in young people: Review of treatment guidelines needed, suggest researchers

Treatment with gabapentinoids — a group of drugs used for epilepsy, nerve pain and anxiety disorders — is associated with an increased risk of suicidal behaviour, unintentional overdose, injuries, and road traffic incidents, finds a study from Sweden published by The BMJ today. Prescriptions have risen steeply in recent years, and gabapentinoids are among the

Broken brain cells repaired in dementia mouse model: If translated to humans, results suggest new directions for combating cognitive decline in elderly

Dysfunctional neurons in the hippocampus of adult female mice modeling dementia can be repaired and reconnected to distant parts of the brain, reports a new study published in JNeurosci. The similarity between the mouse model and the human condition underscores the therapeutic potential of targeting these cells in dementia patients. The hippocampus generates new brain

Older adults expect to lose brain power, but most don’t ask doctors how to prevent dementia: Many in their 50s and early 60s buy supplements or do puzzles in hopes of protecting brain health, but may miss out on effective strategies

Many Americans in their 50s and early 60s are worried about declining brain health, especially if they have loved ones with memory loss and dementia, a new national poll finds. But while the majority of those polled say they take supplements or do puzzles in an effort to stave off brain decline, very few of

Artificial intelligence tool vastly scales up Alzheimer’s research: Machine learning tool automates pathologists’ work to identify disease markers

Researchers at UC Davis and UC San Francisco have found a way to teach a computer to precisely detect one of the hallmarks of Alzheimer’s disease in human brain tissue, delivering a proof of concept for a machine-learning approach to distinguishing critical markers of the disease. Amyloid plaques are clumps of protein fragments in the

Appendix removal associated with development of Parkinson’s disease: Data from 62 million records explores relationship between the gut and the nervous system disorder

Patients who had their appendix removed were more likely to develop Parkinson’s disease than those whose appendix remained in place, according to the largest study to address the relationship between the two conditions. The retrospective study involving more than 62 million patient records from 26 health systems will be presented at Digestive Disease Week® (DDW)

A comprehensive map of how Alzheimer’s affects the brain

MIT researchers have performed the first comprehensive analysis of the genes that are expressed in individual brain cells of patients with Alzheimer’s disease. The results allowed the team to identify distinctive cellular pathways that are affected in neurons and other types of brain cells. This analysis could offer many potential new drug targets for Alzheimer’s,

Researchers define Alzheimer’s-like brain disorder: LATE symptoms resembles Alzheimer’s disease but has different cause

A brain disorder that mimics symptoms of Alzheimer’s disease has been defined with recommended diagnostic criteria and guidelines for advancing future research on the condition. Researchers at Rush University Medical Center and scientists from several National Institutes of Health-funded institutions, in collaboration with international peers, described the newly-named pathway to dementia, Limbic-predominant Age-related TDP-43 Encephalopathy,

Scientists propose new theory on Alzheimer’s, amyloid connection

Worldwide, 50 million people are living with Alzheimer’s disease and other dementias. According to the Alzheimer’s Association, every 65 seconds someone in the United States develops this disease, which causes problems with memory, thinking and behavior. It has been more than 100 years since Alois Alzheimer, M.D., a German psychiatrist and neuropathologist, first reported the

Research reveals how the most common ALS mutation dooms cells: Scientists offer insight into the toxicity at the heart of devastating neurological disorders

St. Jude Children’s Research Hospital scientists have cracked the mystery surrounding the most common genetic cause of amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease. The research suggests possible new approaches to diagnosis and treatment of the lethal disorder. The findings appear online today in the journal Molecular Cell. About 35 percent of ALS cases