Tag: Alzheimer’s

The strongest genetic risk factor for Alzheimer’s disease is the apolipoprotein E type 4 allele (ApoE ε4). Research presented by Manish Paranjpe at the 2019 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) used positron emission tomography (PET) to show that women who are ApoE ε4 carriers and already experiencing mild

Treatment with gabapentinoids — a group of drugs used for epilepsy, nerve pain and anxiety disorders — is associated with an increased risk of suicidal behaviour, unintentional overdose, injuries, and road traffic incidents, finds a study from Sweden published by The BMJ today. Prescriptions have risen steeply in recent years, and gabapentinoids are among the

Various clinical trials indicate what effects can be expected from standardized intervention programs on the basis of existing evidence. Little is known about the way in which such programs can be implemented in actual care practice. However, it may be possible to use data from clinical practice to estimate the potential of drug prescriptions to

Dysfunctional neurons in the hippocampus of adult female mice modeling dementia can be repaired and reconnected to distant parts of the brain, reports a new study published in JNeurosci. The similarity between the mouse model and the human condition underscores the therapeutic potential of targeting these cells in dementia patients. The hippocampus generates new brain

Dementia is the name given to a group of symptoms linked to an ongoing decline in brain function, according to the NHS. There are a number of different types of dementia, but the most common is Alzheimer’s disease. Alzheimer’s is believed to be caused by an abnormal build-up of proteins in and around the brain. You could be

Many Americans in their 50s and early 60s are worried about declining brain health, especially if they have loved ones with memory loss and dementia, a new national poll finds. But while the majority of those polled say they take supplements or do puzzles in an effort to stave off brain decline, very few of

Researchers at UC Davis and UC San Francisco have found a way to teach a computer to precisely detect one of the hallmarks of Alzheimer’s disease in human brain tissue, delivering a proof of concept for a machine-learning approach to distinguishing critical markers of the disease. Amyloid plaques are clumps of protein fragments in the

Patients who had their appendix removed were more likely to develop Parkinson’s disease than those whose appendix remained in place, according to the largest study to address the relationship between the two conditions. The retrospective study involving more than 62 million patient records from 26 health systems will be presented at Digestive Disease Week® (DDW)

MIT researchers have performed the first comprehensive analysis of the genes that are expressed in individual brain cells of patients with Alzheimer’s disease. The results allowed the team to identify distinctive cellular pathways that are affected in neurons and other types of brain cells. This analysis could offer many potential new drug targets for Alzheimer’s,

A brain disorder that mimics symptoms of Alzheimer’s disease has been defined with recommended diagnostic criteria and guidelines for advancing future research on the condition. Researchers at Rush University Medical Center and scientists from several National Institutes of Health-funded institutions, in collaboration with international peers, described the newly-named pathway to dementia, Limbic-predominant Age-related TDP-43 Encephalopathy,

Worldwide, 50 million people are living with Alzheimer’s disease and other dementias. According to the Alzheimer’s Association, every 65 seconds someone in the United States develops this disease, which causes problems with memory, thinking and behavior. It has been more than 100 years since Alois Alzheimer, M.D., a German psychiatrist and neuropathologist, first reported the

St. Jude Children’s Research Hospital scientists have cracked the mystery surrounding the most common genetic cause of amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease. The research suggests possible new approaches to diagnosis and treatment of the lethal disorder. The findings appear online today in the journal Molecular Cell. About 35 percent of ALS cases

Seemingly harmless fluid-filled spaces around the cerebral small vessels, commonly seen on brain MRIs in older adults, are now thought to be associated with more compromised cognitive skills, according to a Vanderbilt University Medical Center study published in Neurology. The new findings challenge longstanding beliefs that these areas — known as perivascular spaces — are

Having a parent with Alzheimer’s disease has been known to raise a person’s risk of developing the disease, but new research suggests that having second- and third-degree relatives who have had Alzheimer’s may also increase risk. The study is published in the March 13, 2019, online issue of Neurology, the medical journal of the American

The medicinal powers of aspirin, digitalis, and the anti-malarial artemisinin all come from plants. A Salk Institute discovery of a potent neuroprotective and anti-inflammatory chemical in a native California shrub may lead to a treatment for Alzheimer’s disease based on a compound found in nature. The research appears in the February 2019 issue of the

A group of more than 60 leading international neuroscientists, including Mark Herceg, PhD, a neuropsychologist at Northwell Health’s Phelps Hospital in Sleepy Hollow, NY, and a member of The Feinstein Institute for Medical Research, published a correspondence today in The Lancet Neurology, asking for balance when reporting on sports-related injury chronic traumatic encephalopathy (CTE). CTE

A research team designed a study to investigate the role depression symptoms play in an increased risk of death over time. The team also examined the role heart disease and stroke play in the link between depression symptoms and increased risk of death. As we age, we become more likely to experience symptoms of depression.

A study of the differences between healthy brains and those with Alzheimer’s Disease has produced largest dataset of its type ever. And the data, developed by a team of researchers led by Dr. Richard Unwin at The University of Manchester, is now freely available online for any scientist to use. The team included researchers from

Having gum disease ‘raises your risk of Alzheimer’s’: Landmark study shows bacteria that can cause bleeding gums is found in the brains of patients with the memory-robbing disorder Porphyromonas gingivalis is a key cause of gum disease and tooth loss  Bacteria’s DNA found in Alzheimer’s patients’ brain tissue and spinal fluid Bug can spread from

Incorporating genetic diversity into a mouse model of Alzheimer’s disease resulted in greater overlap with the genetic, molecular and clinical features of this pervasive human disease, according to a study funded by the National Institute on Aging (NIA), part of the National Institutes of Health. The study also suggests that adding genetic diversity may be