SORLA is a protein trafficking receptor that has been mainly studied in neurons, but it also plays a role in cancer cells. Professor Johanna Ivaska's research group at Turku Bioscience observed that SORLA functionally contributes to the most reported therapy-resistant mechanism by which the cell-surface receptor HER3 counteracts HER2 targeting therapy in HER2-positive cancers. Removing
Neurons, the fundamental units of the brain, are complex computers by themselves. They receive input signals on a tree-like structure—the dendrite. This structure does more than simply collect the input signals: it integrates and compares them to find those special combinations that are important for the neurons’ role in the brain. Moreover, the dendrites of
A major clinical trial in Canada shows that an inexpensive anti-inflammatory drug called colchicine can significantly reduce the risk of complications and death from COVID-19, bringing “important hope” to sufferers, the lead researcher said Sunday. Jean-Claude Tardif, head of the Montreal Heart Institute (ICM), led the study named “Colcorona,” whose preliminary results were published Friday
Scleroderma, a chronic and currently incurable orphan disease where tissue injury causes potentially lethal skin and lung scarring, remains poorly understood. However, the defining characteristic of systemic sclerosis, the most serious form of scleroderma, is irreversible and progressive scarring that affects the skin and internal organs. Published in iScience, Michigan Medicine’s Scleroderma Program and the
HERO-TOGETHER, a new research study, will gain insights on how COVID-19 vaccination can help keep communities healthy and free of the virus. The COVID-19 pandemic is a once-in-a-generation challenge that healthcare heroes everywhere have worked together to face. From working on the front lines to working behind the scenes, people in health care and public
Research led by Si-Qiong June Liu, MD, Ph.D., Professor of Cell Biology and Anatomy at LSU Health New Orleans School of Medicine, discovered a surprising reciprocal interaction between chemicals in the brain resulting in accelerated loss of molecules that regulate brain cell communication. The research team’s findings are published online in Nature Communications, available here.
Florian first came to Wellington in 2014, for a trimester abroad from Göttingen University in Germany, and returned several years later to do his doctoral research. “In Germany it is rare that students can choose their own doctoral topics, so I was grateful for the chance to pursue my interest in gaming.” When he began,
A study led by researchers from the Boston University School of Public Health (BUSPH) claims that Medicaid expansion is not enough to improve the health care for patients with diabetes. According to a study published in the American Journal of Preventive Medicine, the Medicaid expansion which has insured improved healthcare facilities to millions of patients
Studies from a randomised controlled trial reveals the capability of walnuts from preventing major risk factors for heart disease, claims,’ people who regularly consume walnuts may have a lower risk of heart disease, compared to those who do not eat’. In the study, conducted by Dr Emilio Ros from the Hospital Clinic of Barcelona, in
Menarini Silicon Biosystems has announced the publication of a research study providing support for the reliability of using circulating tumor cell (CTC) count to guide frontline therapy choice for patients with estrogen receptor-positive (ER+), HER2-negative (HER2) metastatic breast cancer. Published in the November issue of JAMA Oncology, this is the first study to support clinical
Providing support to help people with prediabetes make small changes to their lifestyle, diet and physical activity can almost halve the risk of developing type 2 diabetes, according the results of the Norfolk Diabetes Prevention Study (NDPS) the largest diabetes prevention research study in the world in the last 30 years. The findings of the
A statistical estimation technique developed by a University of Notre Dame researcher offers public health officials a new way to build short-term forecasts of coronavirus diagnoses and deaths. It also provides additional insight into the effectiveness of earlier pandemic mitigation measures in 30 countries. As the COVID-19 pandemic began to spread globally in early 2020,
A new study from the University of Aberdeen and the University of Bath has found the optimal age at which sense of touch and hearing best work together to compensate for blindness. The research led by Dr. Meike Scheller from the University of Aberdeen found that blindness before the age of eight or nine facilitates
Babies born to mothers who smoked during pregnancy are more likely to suffer from impaired lung development. They are also more susceptible to developing lung diseases such as asthma and chronic obstructive pulmonary disease (COPD), according to a new research article published in the American Journal of Physiology-Lung Cellular and Molecular Physiology. The article has
Lawrence Livermore National Laboratory (LLNL) scientists have paired 3-D-printed, living human brain vasculature with advanced computational flow simulations to better understand tumor cell attachment to blood vessels, the first step in secondary tumor formation during cancer metastasis. The unique approach, developed with outside collaborators, lays the foundation for developing a predictive capability that can help
In the early days of the COVID-19 lockdown in March, many temporary visa holders working in heavily casualised industries, such as hospitality and retail, lost their jobs and struggled to meet basic living expenses. These included international students, backpackers, graduates, sponsored workers and refugees, among others. Despite the devastating financial impact on these temporary migrants,
Science is collaborative by nature, since scientific knowledge only advances, step by step, through combined efforts and findings. Nevertheless, there is often a lack of communication regarding the more technical and everyday advances in laboratory work, and as a result, research progresses less quickly. In recent years, the development of the digital ecosystem has resulted
Why some people age faster than others What exactly happens in the aging? The ability to eliminate waste proteins seems to be both the aging of the brain, as well as on the entire life-span impact. An international research team acquired a new fundamental insights about the process of aging. Researchers from the Leibniz-Institute for
Researchers at Beijing Normal university and Leiden University have recently carried out a study investigating patterns in neural activity that could be observed in humans during intergroup conflicts (i.e., conflicts between different groups of individuals). Their paper, published in Nature Neuroscience, draws inspiration from “The crowd: A study of the popular mind,” a book by
While autism specialists are crucial in the diagnosis and treatment of children with autism, primary care providers are very often the first to care for children with autism spectrum disorder. Two new studies reveal a range of barriers these clinicians face in recognizing and treating autism symptoms, as well as evidence that an innovative tele-mentoring
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